|Description: TFIIH basal transcription factor complex helicase XPB subunit(EC 3.6.1.-) (Basic transcription factor 2 89 kDa subunit) (BTF2-p89)(TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells)(Xeroderma pigmentosum group B-complementing protein) (DNA excisionrepair protein ERCC-3).|
Synonyms: XPB, XPBC
Ensembl ID: ENSG00000163161
UniprotKB/SwissProt: ERCC3_HUMAN (P19447)
Function: ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.