Regulatory Network in Protein Phosphorylation
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Substrate: ERCC3

Description: TFIIH basal transcription factor complex helicase XPB subunit(EC 3.6.1.-) (Basic transcription factor 2 89 kDa subunit) (BTF2-p89)(TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells)(Xeroderma pigmentosum group B-complementing protein) (DNA excisionrepair protein ERCC-3).

Synonyms: XPB, XPBC

Ensembl ID: ENSG00000163161

UniprotKB/SwissProt: ERCC3_HUMAN (P19447)

Function: ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ERCC3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ERCC3ERCC3_HUMANS370GNSAV S VEQWK 21.47% Swiss-Prot 55.0 View   
2ERCC3ERCC3_HUMANS370GNSAV S VEQWK 21.47% Phospho.ELM 7.0View   
3ERCC3ERCC3_HUMANS751TMSSM S GADDT 32.55% HPRD:00593(in vivo)View   
4ERCC3ERCC3_HUMANS751TMSSM S GADDT 32.55%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing