Regulatory Network in Protein Phosphorylation
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Substrate: ESR1

Description: Estrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1).

Synonyms: ESR, NR3A1

Ensembl ID: ENSG00000091831

UniprotKB/SwissProt: ESR1_HUMAN (P03372)

Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ESR1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ESR1ESR1_HUMANT7TMTLH T KASGM 31.27% Swiss-Prot 55.0 View   
2ESR1ESR1_HUMANS10LHTKA S GMALL 30.56% Swiss-Prot 55.0 View   
3ESR1ESR1_HUMANS102FPPLN S VSPSP 31.49%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
4ESR1ESR1_HUMANS102FPPLN S VSPSP 31.49%P51948(MAT1) HPRD:00589(in vitro) ViewAnalyzing
5ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
6ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%CDK2 Swiss-Prot 55.0   ViewAnalyzing
7ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%CDK_group Phospho.ELM 7.0 ViewAnalyzing
8ESR1ESR1_HUMANS104PLNSV S PSPLM 21.34%P51948(MAT1) HPRD:00589(in vitro) ViewAnalyzing
9ESR1ESR1_HUMANS106NSVSP S PLMLL 24.14%CDK_group Phospho.ELM 7.0 ViewAnalyzing
10ESR1ESR1_HUMANS106NSVSP S PLMLL 24.14%P51948(MAT1) HPRD:00589(in vitro) ViewAnalyzing