Regulatory Network in Protein Phosphorylation
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Substrate: F11R

Description: Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesionmolecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (PlateletF11 receptor) (CD321 antigen).

Synonyms: JAM1, JCAM

Ensembl ID: ENSG00000158769

UniprotKB/SwissProt: JAM1_HUMAN (Q9Y624)

Function: Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction, tight junction; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.
PDB:1NBQ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of F11R

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1F11RJAM1_HUMANS34VTVHS S EPEVR 42.14%CK2a1 HPRD:12038(in vitro)  ViewAnalyzing
2F11RJAM1_HUMANS34VTVHS S EPEVR 42.14%CK2a1-rs HPRD:12038(in vitro)  ViewAnalyzing
3F11RJAM1_HUMANT70DQGDT T RLVCY 27.09%PKCa HPRD:12038(in vitro)  ViewAnalyzing
4F11RJAM1_HUMANT92VTFLP T GITFK 43.28%PKCa HPRD:12038(in vitro)  ViewAnalyzing
5F11RJAM1_HUMANS284IYSQP S ARSEG 28.77% Swiss-Prot 55.0 (Similarity)View   
6F11RJAM1_HUMANS287QPSAR S EGEFK 50.06% Swiss-Prot 55.0 (Similarity)View