|Description: Furin precursor (EC 220.127.116.11) (Paired basic amino acid residuecleaving enzyme) (PACE) (Dibasic-processing enzyme).|
Synonyms: FUR, PACE, PCSK3
Ensembl ID: ENSG00000140564
UniprotKB/SwissProt: FURIN_HUMAN (P09958)
Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of