Regulatory Network in Protein Phosphorylation
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Substrate: HDAC1

Description: Histone deacetylase 1 (HD1).

Synonyms: RPD3L1

Ensembl ID: ENSG00000116478

UniprotKB/SwissProt: HDAC1_HUMAN (Q13547)

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1TYI
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HDAC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HDAC1HDAC1_HUMANY221AGKGK Y YAVNY 12.82% Swiss-Prot 55.0 View   
2HDAC1HDAC1_HUMANS393AIPEE S GDEDE 50.29% Swiss-Prot 55.0 View   
3HDAC1HDAC1_HUMANS393AIPEE S GDEDE 50.29% Phospho.ELM 7.0View   
4HDAC1HDAC1_HUMANS421CEEEF S DSEEE 43.43%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
5HDAC1HDAC1_HUMANS421CEEEF S DSEEE 43.43%CK2a1-rs HPRD:03143(in vitro)  ViewAnalyzing
6HDAC1HDAC1_HUMANS421CEEEF S DSEEE 43.43%CK2_group Phospho.ELM 7.0 ViewAnalyzing
7HDAC1HDAC1_HUMANS421CEEEF S DSEEE 43.43%CK2a1 HPRD:03143(in vitro)  ViewAnalyzing
8HDAC1HDAC1_HUMANS421CEEEF S DSEEE 43.43%CK2a2 HPRD:03143(in vitro)  ViewAnalyzing
9HDAC1HDAC1_HUMANS421CEEEF S DSEEE 43.43%CK2_group Swiss-Prot 55.0  ViewAnalyzing
10HDAC1HDAC1_HUMANS423EEFSD S EEEGE 45.79%CK2a2 HPRD:03143(in vitro)  ViewAnalyzing
11HDAC1HDAC1_HUMANS423EEFSD S EEEGE 45.79%CK2a1 HPRD:03143(in vitro)  ViewAnalyzing
12HDAC1HDAC1_HUMANS423EEFSD S EEEGE 45.79%CK2_group Phospho.ELM 7.0 ViewAnalyzing
13HDAC1HDAC1_HUMANS423EEFSD S EEEGE 45.79%CK2_group Swiss-Prot 55.0  ViewAnalyzing
14HDAC1HDAC1_HUMANS423EEFSD S EEEGE 45.79%CK2a1-rs HPRD:03143(in vitro)  ViewAnalyzing
15HDAC1HDAC1_HUMANS423EEFSD S EEEGE 45.79%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing