|Description: Histone deacetylase 2 (HD2).|
Ensembl ID: ENSG00000196591
UniprotKB/SwissProt: HDAC2_HUMAN (Q92769)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.