Regulatory Network in Protein Phosphorylation
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Substrate: HMGA1

Description: High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobilitygroup AT-hook protein 1) (High mobility group protein A1) (Highmobility group protein-R).

Synonyms: HMGIY

Ensembl ID: ENSG00000137309

UniprotKB/SwissProt: HMGA1_HUMAN (P17096)

Function: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:2EZD
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HMGA1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HMGA1HMGA1_HUMANS36KQPPV S PGTAL 24.32% Swiss-Prot 55.0 View   
2HMGA1HMGA1_HUMANS36KQPPV S PGTAL 24.32% HPRD:02829(in vivo)View   
3HMGA1HMGA1_HUMANS44TALVG S QKEPS 30.51% Swiss-Prot 55.0 View   
4HMGA1HMGA1_HUMANS49SQKEP S EVPTP 52.93% Swiss-Prot 55.0 (Similarity)View   
5HMGA1HMGA1_HUMANS49SQKEP S EVPTP 52.93% HPRD:02829(in vivo)View   
6HMGA1HMGA1_HUMANT53PSEVP T PKRPR 46.77% Swiss-Prot 55.0 View   
7HMGA1HMGA1_HUMANT53PSEVP T PKRPR 46.77%CDC2 HPRD:02829(in vitro;in vivo)  ViewAnalyzing
8HMGA1HMGA1_HUMANT53PSEVP T PKRPR 46.77%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
9HMGA1HMGA1_HUMANT78RKTTT T PGRKP 22.96%CDC2 HPRD:02829(in vitro;in vivo)  ViewAnalyzing
10HMGA1HMGA1_HUMANT78RKTTT T PGRKP 22.96%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
11HMGA1HMGA1_HUMANS99EEEGI S QESSE 38.46%CK2a1 HPRD:02829(in vitro)  ViewAnalyzing
12HMGA1HMGA1_HUMANS99EEEGI S QESSE 38.46% Swiss-Prot 55.0 View   
13HMGA1HMGA1_HUMANS99EEEGI S QESSE 38.46%CK2a1-rs HPRD:02829(in vitro)  ViewAnalyzing
14HMGA1HMGA1_HUMANS99EEEGI S QESSE 38.46% HPRD:02829(in vivo)View   
15HMGA1HMGA1_HUMANS99EEEGI S QESSE 38.46%CK2_group Phospho.ELM 7.0 ViewAnalyzing
16HMGA1HMGA1_HUMANS99EEEGI S QESSE 38.46%CK2a2 HPRD:02829(in vitro)  ViewAnalyzing
17HMGA1HMGA1_HUMANS102GISQE S SEEEQ 35.10%CK_group(in isoform HMG-I and isoform HMG-Y) Swiss-Prot 55.0  ViewAnalyzing
18HMGA1HMGA1_HUMANS102GISQE S SEEEQ 35.10% HPRD:02829(in vivo)View   
19HMGA1HMGA1_HUMANS102GISQE S SEEEQ 35.10%CK2a2 HPRD:02829(in vitro)  ViewAnalyzing
20HMGA1HMGA1_HUMANS102GISQE S SEEEQ 35.10%CK2_group Phospho.ELM 7.0 ViewAnalyzing
21HMGA1HMGA1_HUMANS102GISQE S SEEEQ 35.10%CK2a1 HPRD:02829(in vitro)  ViewAnalyzing
22HMGA1HMGA1_HUMANS102GISQE S SEEEQ 35.10%CK2a1-rs HPRD:02829(in vitro)  ViewAnalyzing
23HMGA1HMGA1_HUMANS103ISQES S EEEQ 48.55%CK2_group Phospho.ELM 7.0 ViewAnalyzing
24HMGA1HMGA1_HUMANS103ISQES S EEEQ 48.55% HPRD:02829(in vivo)View   
25HMGA1HMGA1_HUMANS103ISQES S EEEQ 48.55%CK2a1-rs HPRD:02829(in vitro)  ViewAnalyzing
26HMGA1HMGA1_HUMANS103ISQES S EEEQ 48.55%CK2a2 HPRD:02829(in vitro)  ViewAnalyzing
27HMGA1HMGA1_HUMANS103ISQES S EEEQ 48.55%CK_group(in isoform HMG-I and isoform HMG-Y) Swiss-Prot 55.0  ViewAnalyzing
28HMGA1HMGA1_HUMANS103ISQES S EEEQ 48.55%CK2a1 HPRD:02829(in vitro)  ViewAnalyzing