Regulatory Network in Protein Phosphorylation
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Substrate: HNRNPC

Description: Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

Synonyms: HNRPC

Ensembl ID: ENSG00000092199

UniprotKB/SwissProt: HNRPC_HUMAN (P07910)

Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Component of ribonucleosomes.
PDB:1TXP
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HNRNPC

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HNRNPCHNRPC_HUMANS138YDRMY S YPARV 18.46% Swiss-Prot 55.0 View   
2HNRNPCHNRPC_HUMANS162KRQRV S GNTSR 28.63% Phospho.ELM 7.0View   
3HNRNPCHNRPC_HUMANS162KRQRV S GNTSR 28.63% Swiss-Prot 55.0 View   
4HNRNPCHNRPC_HUMANS233MKNDK S EEEQS 53.77% Swiss-Prot 55.0 View   
5HNRNPCHNRPC_HUMANS233MKNDK S EEEQS 53.77% Phospho.ELM 7.0View   
6HNRNPCHNRPC_HUMANS238SEEEQ S SSSVK 35.15% Swiss-Prot 55.0 View   
7HNRNPCHNRPC_HUMANS239EEEQS S SSVKK 26.73% Swiss-Prot 55.0 View   
8HNRNPCHNRPC_HUMANS240EEQSS S SVKKD 44.38%CK1a HPRD:01243(in vitro)  ViewAnalyzing
9HNRNPCHNRPC_HUMANS240EEQSS S SVKKD 44.38% Swiss-Prot 55.0 View   
10HNRNPCHNRPC_HUMANS240EEQSS S SVKKD 44.38% HPRD:01243(in vitro)View   
11HNRNPCHNRPC_HUMANS241EQSSS S VKKDE 39.65% Swiss-Prot 55.0 View   
12HNRNPCHNRPC_HUMANS253NVKME S EGGAD 37.73% Swiss-Prot 55.0 View   
13HNRNPCHNRPC_HUMANS253NVKME S EGGAD 37.73% HPRD:01243(in vitro)View   
14HNRNPCHNRPC_HUMANS253NVKME S EGGAD 37.73%CK1a HPRD:01243(in vitro)  ViewAnalyzing
15HNRNPCHNRPC_HUMANS253NVKME S EGGAD 37.73%CK1a(CK1 alpha) Phospho.ELM 7.0 ViewAnalyzing
16HNRNPCHNRPC_HUMANS260GGADD S AEEGD 37.82%CK2a1 HPRD:01243(in vitro;in vivo)  ViewAnalyzing
17HNRNPCHNRPC_HUMANS260GGADD S AEEGD 37.82%CK2_group Phospho.ELM 7.0 ViewAnalyzing
18HNRNPCHNRPC_HUMANS260GGADD S AEEGD 37.82%CK1a(CK1 alpha) Phospho.ELM 7.0 ViewAnalyzing
19HNRNPCHNRPC_HUMANS260GGADD S AEEGD 37.82%CK2a2 HPRD:01243(in vitro;in vivo)  ViewAnalyzing
20HNRNPCHNRPC_HUMANS260GGADD S AEEGD 37.82% Swiss-Prot 55.0 View   
21HNRNPCHNRPC_HUMANS260GGADD S AEEGD 37.82%CK2a1-rs HPRD:01243(in vitro;in vivo)  ViewAnalyzing
22HNRNPCHNRPC_HUMANS299EDDRD S ANGED 25.24%CK1a(CK1 alpha) Phospho.ELM 7.0 ViewAnalyzing
23HNRNPCHNRPC_HUMANS299EDDRD S ANGED 25.24% HPRD:01243(in vitro)View   
24HNRNPCHNRPC_HUMANS299EDDRD S ANGED 25.24% Swiss-Prot 55.0 View   
25HNRNPCHNRPC_HUMANS306NGEDD S  55.21% Phospho.ELM 7.0View