Regulatory Network in Protein Phosphorylation
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Substrate: HSF1

Description: Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1).

Synonyms: HSTF1

Ensembl ID: ENSG00000185122

UniprotKB/SwissProt: HSF1_HUMAN (Q00613)

Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HSF1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HSF1HSF1_HUMANS121KRKVT S VSTLK 19.63%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
2HSF1HSF1_HUMANT142VTKLL T DVQLM 44.56%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
3HSF1HSF1_HUMANT142VTKLL T DVQLM 44.56%CK2a1 HPRD:00778(in vitro)  ViewAnalyzing
4HSF1HSF1_HUMANT142VTKLL T DVQLM 44.56%CK2_group Phospho.ELM 7.0 ViewAnalyzing
5HSF1HSF1_HUMANT142VTKLL T DVQLM 44.56%CK2a1-rs HPRD:00778(in vitro)  ViewAnalyzing
6HSF1HSF1_HUMANS230YSRQF S LEHVH 25.22%CaMK2_group Phospho.ELM 7.0 ViewAnalyzing
7HSF1HSF1_HUMANS230YSRQF S LEHVH 25.22%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
8HSF1HSF1_HUMANS230YSRQF S LEHVH 25.22%CaMK2a HPRD:00778(in vitro;in vivo)  ViewAnalyzing
9HSF1HSF1_HUMANS292RPLSS S PLVRV 20.91% Phospho.ELM 7.0View   
10HSF1HSF1_HUMANS303KEEPP S PPQSP 60.99% Swiss-Prot 55.0 View   
11HSF1HSF1_HUMANS303KEEPP S PPQSP 60.99%GSK3A HPRD:00778(in vitro;in vivo)  ViewAnalyzing
12HSF1HSF1_HUMANS303KEEPP S PPQSP 60.99%GSK_group Phospho.ELM 7.0 ViewAnalyzing
13HSF1HSF1_HUMANS303KEEPP S PPQSP 60.99% HPRD:00778(in vivo)View   
14HSF1HSF1_HUMANS307PSPPQ S PRVEE 22.05%Erk1 HPRD:00778(in vitro;in vivo)  ViewAnalyzing
15HSF1HSF1_HUMANS307PSPPQ S PRVEE 22.05% HPRD:00778(in vivo)View   
16HSF1HSF1_HUMANS307PSPPQ S PRVEE 22.05%MAPK_group Phospho.ELM 7.0 ViewAnalyzing
17HSF1HSF1_HUMANS307PSPPQ S PRVEE 22.05% Swiss-Prot 55.0 View   
18HSF1HSF1_HUMANS314RVEEA S PGRPS 31.03% Phospho.ELM 7.0View   
19HSF1HSF1_HUMANS319SPGRP S SVDTL 41.45% Phospho.ELM 7.0View   
20HSF1HSF1_HUMANT323PSSVD T LLSPT 27.69% Swiss-Prot 55.0 View   
21HSF1HSF1_HUMANT323PSSVD T LLSPT 27.69% Phospho.ELM 7.0View   
22HSF1HSF1_HUMANS326VDTLL S PTALI 24.26% Phospho.ELM 7.0View   
23HSF1HSF1_HUMANS326VDTLL S PTALI 24.26% HPRD:00778(in vitro)View   
24HSF1HSF1_HUMANS344EPAPA S VTALT 20.95% Phospho.ELM 7.0View   
25HSF1HSF1_HUMANS363EGRPP S PPPTS 53.36% Swiss-Prot 55.0 View   
26HSF1HSF1_HUMANS363EGRPP S PPPTS 53.36%JNK1 HPRD:00778(in vitro;in vivo)  ViewAnalyzing
27HSF1HSF1_HUMANS363EGRPP S PPPTS 53.36%JNK_group Phospho.ELM 7.0 ViewAnalyzing
28HSF1HSF1_HUMANS419LLDLF S PSVTV 24.46% Phospho.ELM 7.0View   
29HSF1HSF1_HUMANS444IQELL S PQEPP 36.84% Phospho.ELM 7.0View