Regulatory Network in Protein Phosphorylation
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Substrate: HSPH1

Description: Heat shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY-CO-25).

Synonyms: HSP105, HSP110, KIAA0201

Ensembl ID: ENSG00000120694

UniprotKB/SwissProt: HS105_HUMAN (Q92598)

Function: Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HSPH1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HSPH1HS105_HUMANS31IANEF S DRCTP 20.26% Swiss-Prot 55.0 View   
2HSPH1HS105_HUMANS384QCAIL S PAFKV 14.20% Swiss-Prot 55.0 View   
3HSPH1HS105_HUMANS509EENEM S SEADM 20.88% Swiss-Prot 55.0 (Similarity)View   
4HSPH1HS105_HUMANS509EENEM S SEADM 20.88%CK2a1 HPRD:09990(in vitro)  ViewAnalyzing
5HSPH1HS105_HUMANS509EENEM S SEADM 20.88%CK2a2 HPRD:09990(in vitro)  ViewAnalyzing
6HSPH1HS105_HUMANS509EENEM S SEADM 20.88%CK2a1-rs HPRD:09990(in vitro)  ViewAnalyzing
7HSPH1HS105_HUMANS557SQSPP S PELTS 34.10% Swiss-Prot 55.0 View   
8HSPH1HS105_HUMANS557SQSPP S PELTS 34.10% HPRD:09990(in vitro)View   
9HSPH1HS105_HUMANS809KPKIE S PKLER 30.70% Phospho.ELM 7.0View   
10HSPH1HS105_HUMANS809KPKIE S PKLER 30.70% Swiss-Prot 55.0 View   
11HSPH1HS105_HUMANS809KPKIE S PKLER 30.70% HPRD:09990(in vivo)View   
12HSPH1HS105_HUMANT815PKLER T PNGPN 16.25% Swiss-Prot 55.0 View