Regulatory Network in Protein Phosphorylation
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Substrate: IGF2R

Description: Cation-independent mannose-6-phosphate receptor precursor (CI Man-6-Preceptor) (CI-MPR) (M6PR) (Insulin-like growth factor 2 receptor)(Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2receptor) (M6P/IGF2R) (300 kDa mannose 6-phosphate receptor) (MPR 300)(MPR300) (CD222 antigen).

Synonyms: MPRI

Ensembl ID: ENSG00000197081

UniprotKB/SwissProt: MPRI_HUMAN (P11717)

Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Lysosome membrane; Single-pass type I membrane protein.
PDB:1E6F
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of IGF2R

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1IGF2RMPRI_HUMANS2409GDDQD S EDEVL 41.12% Swiss-Prot 55.0 View   
2IGF2RMPRI_HUMANS2409GDDQD S EDEVL 41.12%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
3IGF2RMPRI_HUMANS2479STKLV S FHDDS 27.57% Swiss-Prot 55.0 View   
4IGF2RMPRI_HUMANS2479STKLV S FHDDS 27.57% Phospho.ELM 7.0View   
5IGF2RMPRI_HUMANS2484SFHDD S DEDLL 49.29% Swiss-Prot 55.0 View   
6IGF2RMPRI_HUMANS2484SFHDD S DEDLL 49.29%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing