Regulatory Network in Protein Phosphorylation
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Substrate: IGFBP3

Description: Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP-3) (IGF-binding protein 3).

Synonyms: IBP3

Ensembl ID: ENSG00000146674

UniprotKB/SwissProt: IBP3_HUMAN (P17936)

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of IGFBP3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1IGFBP3IBP3_HUMANS138APGNA S ESEED 45.73%CK2a1-rs HPRD:00899(in vitro;in vivo)  ViewAnalyzing
2IGFBP3IBP3_HUMANS138APGNA S ESEED 45.73%CK2a1 HPRD:00899(in vitro;in vivo)  ViewAnalyzing
3IGFBP3IBP3_HUMANS138APGNA S ESEED 45.73%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4IGFBP3IBP3_HUMANS140GNASE S EEDRS 43.73%CK2a1-rs HPRD:00899(in vitro;in vivo)  ViewAnalyzing
5IGFBP3IBP3_HUMANS140GNASE S EEDRS 43.73%CK2a1 HPRD:00899(in vitro;in vivo)  ViewAnalyzing
6IGFBP3IBP3_HUMANS140GNASE S EEDRS 43.73%CK2_group Phospho.ELM 7.0 ViewAnalyzing