Regulatory Network in Protein Phosphorylation
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Substrate: LIG1

Description: DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotidesynthase [ATP] 1).

Ensembl ID: ENSG00000105486

UniprotKB/SwissProt: DNL1_HUMAN (P18858)

Function: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1X9N
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of LIG1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1LIG1DNL1_HUMANS47WNGVV S ESDSP 29.04% Phospho.ELM 7.0View   
2LIG1DNL1_HUMANS49GVVSE S DSPVK 35.56% Swiss-Prot 55.0 View   
3LIG1DNL1_HUMANS49GVVSE S DSPVK 35.56% Phospho.ELM 7.0View   
4LIG1DNL1_HUMANS51VSESD S PVKRP 40.65% Swiss-Prot 55.0 View   
5LIG1DNL1_HUMANS51VSESD S PVKRP 40.65% Phospho.ELM 7.0View   
6LIG1DNL1_HUMANS66ARVLG S EGEEE 37.96% Swiss-Prot 55.0 View   
7LIG1DNL1_HUMANS66ARVLG S EGEEE 37.96%CK2_group Phospho.ELM 7.0 ViewAnalyzing
8LIG1DNL1_HUMANS66ARVLG S EGEEE 37.96%CK2a1-rs HPRD:00534(in vivo)  ViewAnalyzing
9LIG1DNL1_HUMANS66ARVLG S EGEEE 37.96%CK2a1 HPRD:00534(in vivo)  ViewAnalyzing
10LIG1DNL1_HUMANS76EDEAL S PAKGQ 29.84% Phospho.ELM 7.0View   
11LIG1DNL1_HUMANS76EDEAL S PAKGQ 29.84% HPRD:00534(in vivo)View   
12LIG1DNL1_HUMANS76EDEAL S PAKGQ 29.84% Swiss-Prot 55.0 View   
13LIG1DNL1_HUMANS141VLEEQ S EDEDR 50.74% Swiss-Prot 55.0 View   
14LIG1DNL1_HUMANS141VLEEQ S EDEDR 50.74% Phospho.ELM 7.0View   
15LIG1DNL1_HUMANS141VLEEQ S EDEDR 50.74% HPRD:00534(in vivo)View   
16LIG1DNL1_HUMANT195TSKAE T PTESV 40.13% Phospho.ELM 7.0View   
17LIG1DNL1_HUMANT195TSKAE T PTESV 40.13% HPRD:00534(in vivo)View   
18LIG1DNL1_HUMANT195TSKAE T PTESV 40.13% Swiss-Prot 55.0 View   
19LIG1DNL1_HUMANS201PTESV S EPEVA 57.63% Phospho.ELM 7.0View   
20LIG1DNL1_HUMANS201PTESV S EPEVA 57.63% Swiss-Prot 55.0 View   
21LIG1DNL1_HUMANS230PKTLS S FFTPR 27.73% Swiss-Prot 55.0 View   
22LIG1DNL1_HUMANT233LSSFF T PRKPA 21.85% Swiss-Prot 55.0 View   
23LIG1DNL1_HUMANT233LSSFF T PRKPA 21.85% Phospho.ELM 7.0View   
24LIG1DNL1_HUMANS911QQGED S GSDPE 35.57% HPRD:00534(in vivo)View   
25LIG1DNL1_HUMANS911QQGED S GSDPE 35.57% Swiss-Prot 55.0 View   
26LIG1DNL1_HUMANS911QQGED S GSDPE 35.57% Phospho.ELM 7.0View