|Description: Phosphofurin acidic cluster sorting protein 1 (PACS-1).|
Ensembl ID: ENSG00000175115
UniprotKB/SwissProt: PACS1_HUMAN (Q6VY07)
Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, trans-Golgi network (By similarity). Note=Localizes in the perinuclear region, probably the TGN (By similarity).