Regulatory Network in Protein Phosphorylation
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Substrate: PGR

Description: Progesterone receptor (PR) (Nuclear receptor subfamily 3 group Cmember 3).

Synonyms: NR3C3

Ensembl ID: ENSG00000082175

UniprotKB/SwissProt: PRGR_HUMAN (P06401)

Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1A28
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PGR

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PGRPRGR_HUMANS20AGGPP S PEVGS 36.50% Swiss-Prot 55.0 View   
2PGRPRGR_HUMANS20AGGPP S PEVGS 36.50% Phospho.ELM 7.0View   
3PGRPRGR_HUMANS25SPEVG S PLLCR 19.97%CDK2 Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
4PGRPRGR_HUMANT41FPGSQ T SDTLP 30.21%CK_group Swiss-Prot 55.0  ViewAnalyzing
5PGRPRGR_HUMANS81DQQSL S DVEGA 44.87%CK2a1 HPRD:07077(in vitro)  ViewAnalyzing
6PGRPRGR_HUMANS81DQQSL S DVEGA 44.87%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
7PGRPRGR_HUMANS81DQQSL S DVEGA 44.87%CK2_group Phospho.ELM 7.0 ViewAnalyzing
8PGRPRGR_HUMANS81DQQSL S DVEGA 44.87%CK2a1-rs HPRD:07077(in vitro)  ViewAnalyzing
9PGRPRGR_HUMANS102GGSSS S PPEKD 46.55% Swiss-Prot 55.0 View   
10PGRPRGR_HUMANS102GGSSS S PPEKD 46.55% Phospho.ELM 7.0View   
11PGRPRGR_HUMANS130GQSQP S PPACE 35.56% Swiss-Prot 55.0 View   
12PGRPRGR_HUMANS130GQSQP S PPACE 35.56% Phospho.ELM 7.0View   
13PGRPRGR_HUMANS162TQRVL S PLMSR 17.09%CDK2 Phospho.ELM 7.0  ViewAnalyzing
14PGRPRGR_HUMANS162TQRVL S PLMSR 17.09% Swiss-Prot 55.0 View   
15PGRPRGR_HUMANS190LPRGL S PARQL 21.24% Swiss-Prot 55.0 View   
16PGRPRGR_HUMANS190LPRGL S PARQL 21.24%CDK2 Phospho.ELM 7.0  ViewAnalyzing
17PGRPRGR_HUMANS213APVKP S PQAAA 24.75% Swiss-Prot 55.0 View   
18PGRPRGR_HUMANS213APVKP S PQAAA 24.75%CDK2 Phospho.ELM 7.0  ViewAnalyzing
19PGRPRGR_HUMANS227EEEDG S ESEES 50.72%CK_group Swiss-Prot 55.0  ViewAnalyzing
20PGRPRGR_HUMANS232SESEE S AGPLL 34.18%CK_group Swiss-Prot 55.0  ViewAnalyzing
21PGRPRGR_HUMANS294MAPGR S PLATT 30.13%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
22PGRPRGR_HUMANS294MAPGR S PLATT 30.13%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
23PGRPRGR_HUMANS345APPRS S PCASS 25.85% Phospho.ELM 7.0View   
24PGRPRGR_HUMANS345APPRS S PCASS 25.85% Swiss-Prot 55.0 View   
25PGRPRGR_HUMANS400EASAR S PRSYL 25.12%CDK2 Phospho.ELM 7.0  ViewAnalyzing
26PGRPRGR_HUMANT430LPPRA T PSRPG 24.07%CDK2 Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
27PGRPRGR_HUMANS552PDSEA S QSPQY 27.43%CK_group Swiss-Prot 55.0  ViewAnalyzing
28PGRPRGR_HUMANS554SEASQ S PQYSF 16.10%CDK2 Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
29PGRPRGR_HUMANS676QRFTF S PGQDI 25.68%CDK2 Phospho.ELM 7.0  ViewAnalyzing
30PGRPRGR_HUMANS676QRFTF S PGQDI 25.68% Swiss-Prot 55.0 View   
31PGRPRGR_HUMANS793RMKES S FYSLC 29.33%CK_group Swiss-Prot 55.0  ViewAnalyzing