Regulatory Network in Protein Phosphorylation
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Substrate: PKD2

Description: Polycystin-2 (Polycystic kidney disease 2 protein) (Autosomal dominantpolycystic kidney disease type II protein) (Polycystwin) (R48321).

Ensembl ID: ENSG00000118762

UniprotKB/SwissProt: PKD2_HUMAN (Q13563)

Function: Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein (Potential).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PKD2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PKD2PKD2_HUMANS166GPPCP S PVGGG 38.65% Swiss-Prot 55.0 View   
2PKD2PKD2_HUMANS254YTRMM S QLFLD 17.87% Swiss-Prot 55.0 View   
3PKD2PKD2_HUMANT260QLFLD T PVSKT 27.95% Swiss-Prot 55.0 View   
4PKD2PKD2_HUMANS263LDTPV S KTEKT 34.75% Swiss-Prot 55.0 View   
5PKD2PKD2_HUMANS812RSLDD S EEDDD 42.42%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
6PKD2PKD2_HUMANS852DRMEH S IGSIV 18.48% Swiss-Prot 55.0 View   
7PKD2PKD2_HUMANS858IGSIV S KIDAV 23.40% Swiss-Prot 55.0 View