Regulatory Network in Protein Phosphorylation
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Substrate: POLR2F

Description: DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNApolymerases I, II, and III subunit ABC2) (DNA-directed RNA polymeraseII subunit F) (RPB6) (DNA-directed RNA polymerases I, II, and III 14.4kDa polypeptide) (RPABC14.4) (RPB14.4) (RPC15).

Synonyms: POLRF

Ensembl ID: ENSG00000100142

UniprotKB/SwissProt: RPAB2_HUMAN (P61218)

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1QKL
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of POLR2F

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1POLR2FRPAB2_HUMANS2----M S DNEDN 49.49%CK2_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2POLR2FRPAB2_HUMANS2----M S DNEDN 49.49%CK2_group Phospho.ELM 7.0 ViewAnalyzing