Regulatory Network in Protein Phosphorylation
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Substrate: PSEN2

Description: Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5)[Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

Synonyms: AD4, PS2, PSNL2, STM2

Ensembl ID: ENSG00000143801

UniprotKB/SwissProt: PSN2_HUMAN (P49810)

Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PSEN2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PSEN2PSN2_HUMANS7LTFMA S DSEEE 29.86%CK2a1-rs HPRD:02860(in vitro)  ViewAnalyzing
2PSEN2PSN2_HUMANS7LTFMA S DSEEE 29.86%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
3PSEN2PSN2_HUMANS7LTFMA S DSEEE 29.86%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4PSEN2PSN2_HUMANS7LTFMA S DSEEE 29.86%CK2a1 HPRD:02860(in vitro)  ViewAnalyzing
5PSEN2PSN2_HUMANS7LTFMA S DSEEE 29.86%CK1d HPRD:02860(in vitro)  ViewAnalyzing
6PSEN2PSN2_HUMANS7LTFMA S DSEEE 29.86%CK1a HPRD:02860(in vitro)  ViewAnalyzing
7PSEN2PSN2_HUMANS7LTFMA S DSEEE 29.86%CK1_group Phospho.ELM 7.0 ViewAnalyzing
8PSEN2PSN2_HUMANS9FMASD S EEEVC 44.40%CK1_group Phospho.ELM 7.0 ViewAnalyzing
9PSEN2PSN2_HUMANS9FMASD S EEEVC 44.40%CK2_group Phospho.ELM 7.0 ViewAnalyzing
10PSEN2PSN2_HUMANS9FMASD S EEEVC 44.40%CK1d HPRD:02860(in vitro)  ViewAnalyzing
11PSEN2PSN2_HUMANS9FMASD S EEEVC 44.40%CK2a1 HPRD:02860(in vitro)  ViewAnalyzing
12PSEN2PSN2_HUMANS9FMASD S EEEVC 44.40%CK2a1-rs HPRD:02860(in vitro)  ViewAnalyzing
13PSEN2PSN2_HUMANS9FMASD S EEEVC 44.40%CK1a HPRD:02860(in vitro)  ViewAnalyzing
14PSEN2PSN2_HUMANS9FMASD S EEEVC 44.40%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
15PSEN2PSN2_HUMANS19CDERT S LMSAE 28.44%CK2_group Phospho.ELM 7.0 ViewAnalyzing
16PSEN2PSN2_HUMANS19CDERT S LMSAE 28.44%CK2a1-rs HPRD:02860(in vitro)  ViewAnalyzing
17PSEN2PSN2_HUMANS19CDERT S LMSAE 28.44%CK2a1 HPRD:02860(in vitro)  ViewAnalyzing
18PSEN2PSN2_HUMANS19CDERT S LMSAE 28.44%CK1d HPRD:02860(in vitro)  ViewAnalyzing
19PSEN2PSN2_HUMANS19CDERT S LMSAE 28.44%CK1_group Phospho.ELM 7.0 ViewAnalyzing
20PSEN2PSN2_HUMANS19CDERT S LMSAE 28.44%CK1a HPRD:02860(in vitro)  ViewAnalyzing
21PSEN2PSN2_HUMANS327EMEED S YDSFG 33.83%CK1d(CK1 delta) Phospho.ELM 7.0 ViewAnalyzing
22PSEN2PSN2_HUMANS327EMEED S YDSFG 33.83%CK1d HPRD:02860(in vitro;in vivo)  ViewAnalyzing
23PSEN2PSN2_HUMANS330EDSYD S FGEPS 27.24%CK2a1-rs HPRD:02860(in vitro;in vivo)  ViewAnalyzing
24PSEN2PSN2_HUMANS330EDSYD S FGEPS 27.24%CK1d HPRD:02860(in vitro;in vivo)  ViewAnalyzing
25PSEN2PSN2_HUMANS330EDSYD S FGEPS 27.24%CK1d(CK1 delta) Phospho.ELM 7.0 ViewAnalyzing
26PSEN2PSN2_HUMANS330EDSYD S FGEPS 27.24%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
27PSEN2PSN2_HUMANS330EDSYD S FGEPS 27.24%CK2a1 HPRD:02860(in vitro;in vivo)  ViewAnalyzing
28PSEN2PSN2_HUMANS335SFGEP S YPEVF 49.36%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
29PSEN2PSN2_HUMANS335SFGEP S YPEVF 49.36%CK2_group Phospho.ELM 7.0 ViewAnalyzing
30PSEN2PSN2_HUMANS335SFGEP S YPEVF 49.36%CK1d HPRD:02860(in vivo)  ViewAnalyzing
31PSEN2PSN2_HUMANS335SFGEP S YPEVF 49.36%CK2a1-rs HPRD:02860(in vitro;in vivo)  ViewAnalyzing
32PSEN2PSN2_HUMANS335SFGEP S YPEVF 49.36%CK2a1 HPRD:02860(in vitro;in vivo)  ViewAnalyzing