Regulatory Network in Protein Phosphorylation
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Substrate: PTPRC

Description: Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45antigen).

Synonyms: CD45

Ensembl ID: ENSG00000081237

UniprotKB/SwissProt: CD45_HUMAN (P08575)

Function: Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1YGR
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PTPRC

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PTPRCCD45_HUMANS951FQRLP S YRSWR 37.46% HPRD:01050(in vivo)View   
2PTPRCCD45_HUMANS954LPSYR S WRTQH 16.81% HPRD:01050(in vivo)View   
3PTPRCCD45_HUMANS995EMSKE S EHDSD 43.92% Swiss-Prot 55.0 View   
4PTPRCCD45_HUMANS995EMSKE S EHDSD 43.92% HPRD:01050(in vivo)View   
5PTPRCCD45_HUMANS995EMSKE S EHDSD 43.92% Phospho.ELM 7.0View   
6PTPRCCD45_HUMANS999ESEHD S DESSD 45.22%CK2a2 HPRD:01050(in vivo)  ViewAnalyzing
7PTPRCCD45_HUMANS999ESEHD S DESSD 45.22%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
8PTPRCCD45_HUMANS999ESEHD S DESSD 45.22%CK2a1 HPRD:01050(in vivo)  ViewAnalyzing
9PTPRCCD45_HUMANS999ESEHD S DESSD 45.22%CK2_group Phospho.ELM 7.0 ViewAnalyzing
10PTPRCCD45_HUMANS999ESEHD S DESSD 45.22%CK2a1-rs HPRD:01050(in vivo)  ViewAnalyzing
11PTPRCCD45_HUMANS1002HDSDE S SDDDS 44.02%CK2_group Phospho.ELM 7.0 ViewAnalyzing
12PTPRCCD45_HUMANS1002HDSDE S SDDDS 44.02%CK2a1-rs HPRD:01050(in vivo)  ViewAnalyzing
13PTPRCCD45_HUMANS1002HDSDE S SDDDS 44.02% HPRD:01050(in vivo)View   
14PTPRCCD45_HUMANS1002HDSDE S SDDDS 44.02%CK2a2 HPRD:01050(in vivo)  ViewAnalyzing
15PTPRCCD45_HUMANS1002HDSDE S SDDDS 44.02%CK2a1 HPRD:01050(in vivo)  ViewAnalyzing
16PTPRCCD45_HUMANS1002HDSDE S SDDDS 44.02%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
17PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91% HPRD:01050(in vivo)View   
18PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91%CK2a1-rs HPRD:01050(in vivo)  ViewAnalyzing
19PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
20PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91% HPRD:01050(in vivo)View   
21PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91% Swiss-Prot 55.0 View   
22PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91%CK2a2 HPRD:01050(in vivo)  ViewAnalyzing
23PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91%CK2_group Phospho.ELM 7.0 ViewAnalyzing
24PTPRCCD45_HUMANS1003DSDES S DDDSD 42.91%CK2a1 HPRD:01050(in vivo)  ViewAnalyzing
25PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45%CK2a1 HPRD:01050(in vivo)  ViewAnalyzing
26PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45%CK2a1-rs HPRD:01050(in vivo)  ViewAnalyzing
27PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45% HPRD:01050(in vivo)View   
28PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45% Swiss-Prot 55.0 View   
29PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45%PKC_group Phospho.ELM 7.0 ViewAnalyzing
30PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
31PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45%CK2a2 HPRD:01050(in vivo)  ViewAnalyzing
32PTPRCCD45_HUMANS1007SSDDD S DSEEP 50.45% HPRD:01050(in vivo)View   
33PTPRCCD45_HUMANS1019KYINA S FIMSY 15.71% HPRD:01050(in vivo)View   
34PTPRCCD45_HUMANY1216STFEQ Y QFLYD 8.27%Csk Phospho.ELM 7.0  ViewAnalyzing