Regulatory Network in Protein Phosphorylation
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Substrate: RNPS1

Description: RNA-binding protein with serine-rich domain 1 (SR-related proteinLDC2).

Synonyms: LDC2

Ensembl ID: ENSG00000205937

UniprotKB/SwissProt: RNPS1_HUMAN (Q15287)

Function: Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Participates in mRNA 3'-end cleavage. Involved in RENT2-dependent nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RNPS1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RNPS1RNPS1_HUMANS27STRAP S PTKRK 44.19% Swiss-Prot 55.0 View   
2RNPS1RNPS1_HUMANS27STRAP S PTKRK 44.19% Phospho.ELM 7.0View   
3RNPS1RNPS1_HUMANS53ATKES S EKDRG 50.16%CK2_group Swiss-Prot 55.0  ViewAnalyzing
4RNPS1RNPS1_HUMANS53ATKES S EKDRG 50.16%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
5RNPS1RNPS1_HUMANS125SSGSP S PSRRR 36.89% Swiss-Prot 55.0 View   
6RNPS1RNPS1_HUMANS155ERKRR S PSPKP 33.49% HPRD:07341(in vivo)View   
7RNPS1RNPS1_HUMANS155ERKRR S PSPKP 33.49% Swiss-Prot 55.0 View   
8RNPS1RNPS1_HUMANS155ERKRR S PSPKP 33.49% Phospho.ELM 7.0View   
9RNPS1RNPS1_HUMANS157KRRSP S PKPTK 46.96% HPRD:07341(in vivo)View   
10RNPS1RNPS1_HUMANS157KRRSP S PKPTK 46.96% Phospho.ELM 7.0View   
11RNPS1RNPS1_HUMANS157KRRSP S PKPTK 46.96% Swiss-Prot 55.0 View   
12RNPS1RNPS1_HUMANT161PSPKP T KVHIG 52.40% Phospho.ELM 7.0View   
13RNPS1RNPS1_HUMANY205HLSKG Y AYVEF 9.86% Swiss-Prot 55.0 View   
14RNPS1RNPS1_HUMANY205HLSKG Y AYVEF 9.86% Phospho.ELM 7.0View   
15RNPS1RNPS1_HUMANS251PPRRF S PPRRM 31.98% Phospho.ELM 7.0View   
16RNPS1RNPS1_HUMANS251PPRRF S PPRRM 31.98% Swiss-Prot 55.0 View   
17RNPS1RNPS1_HUMANS266PMWRR S PPRMR 30.59% Phospho.ELM 7.0View   
18RNPS1RNPS1_HUMANS266PMWRR S PPRMR 30.59% Swiss-Prot 55.0 View   
19RNPS1RNPS1_HUMANS281SPRRR S PVRRR 26.40% Phospho.ELM 7.0View   
20RNPS1RNPS1_HUMANS287PVRRR S RSPGR 34.99% Swiss-Prot 55.0 View   
21RNPS1RNPS1_HUMANS287PVRRR S RSPGR 34.99% Phospho.ELM 7.0View   
22RNPS1RNPS1_HUMANS289RRRSR S PGRRR 32.71% Phospho.ELM 7.0View   
23RNPS1RNPS1_HUMANS289RRRSR S PGRRR 32.71% Swiss-Prot 55.0 View