|Description: RNA-binding protein with serine-rich domain 1 (SR-related proteinLDC2).|
Ensembl ID: ENSG00000205937
UniprotKB/SwissProt: RNPS1_HUMAN (Q15287)
Function: Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Participates in mRNA 3'-end cleavage. Involved in RENT2-dependent nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein.