Regulatory Network in Protein Phosphorylation
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Substrate: SAT1

Description: Diamine acetyltransferase 1 (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) (Putrescine acetyltransferase)(Polyamine N-acetyltransferase 1).

Synonyms: SAT

Ensembl ID: ENSG00000130066

UniprotKB/SwissProt: SAT1_HUMAN (P21673)

Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:2B3U
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SAT1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SAT1SAT1_HUMANT10VIRPA T AADCS 25.68%CK2a1 HPRD:02431(in vitro)  ViewAnalyzing
2SAT1SAT1_HUMANT10VIRPA T AADCS 25.68%CK2a2 HPRD:02431(in vitro)  ViewAnalyzing
3SAT1SAT1_HUMANT10VIRPA T AADCS 25.68%CK2a1-rs HPRD:02431(in vitro)  ViewAnalyzing
4SAT1SAT1_HUMANT10VIRPA T AADCS 25.68%CK2_group Phospho.ELM 7.0 ViewAnalyzing
5SAT1SAT1_HUMANS146KRRGA S DLSSE 41.74%CK2a1 HPRD:02431(in vitro)  ViewAnalyzing
6SAT1SAT1_HUMANS146KRRGA S DLSSE 41.74%CK2a2 HPRD:02431(in vitro)  ViewAnalyzing
7SAT1SAT1_HUMANS146KRRGA S DLSSE 41.74%CK2a1-rs HPRD:02431(in vitro)  ViewAnalyzing
8SAT1SAT1_HUMANS146KRRGA S DLSSE 41.74%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9SAT1SAT1_HUMANS149GASDL S SEEGW 40.47%CK2a2 HPRD:02431(in vitro)  ViewAnalyzing
10SAT1SAT1_HUMANS149GASDL S SEEGW 40.47%CK2a1 HPRD:02431(in vitro)  ViewAnalyzing
11SAT1SAT1_HUMANS149GASDL S SEEGW 40.47%CK2a1-rs HPRD:02431(in vitro)  ViewAnalyzing
12SAT1SAT1_HUMANS149GASDL S SEEGW 40.47%CK2_group Phospho.ELM 7.0 ViewAnalyzing