Regulatory Network in Protein Phosphorylation
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Substrate: SPP1

Description: Osteopontin precursor (Bone sialoprotein 1) (Secreted phosphoprotein1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

Synonyms: BNSP, OPN

Ensembl ID: ENSG00000118785

UniprotKB/SwissProt: OSTP_HUMAN (P10451)

Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SPP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SPP1OSTP_HUMANS24VKQAD S GSSEE 43.52% Swiss-Prot 55.0 View   
2SPP1OSTP_HUMANS26QADSG S SEEKQ 38.23% Swiss-Prot 55.0 View   
3SPP1OSTP_HUMANS27ADSGS S EEKQL 53.99% Swiss-Prot 55.0 View   
4SPP1OSTP_HUMANS62PQNAV S SEETN 29.62% Swiss-Prot 55.0 View   
5SPP1OSTP_HUMANS63QNAVS S EETND 32.62% Swiss-Prot 55.0 View   
6SPP1OSTP_HUMANT66VSSEE T NDFKQ 35.72% Swiss-Prot 55.0 View   
7SPP1OSTP_HUMANS76QETLP S KSNES 52.40% Swiss-Prot 55.0 View   
8SPP1OSTP_HUMANS81SKSNE S HDHMD 38.17% Swiss-Prot 55.0 View   
9SPP1OSTP_HUMANS99DDHVD S QDSID 34.49% Swiss-Prot 55.0 View   
10SPP1OSTP_HUMANS102VDSQD S IDSND 22.21% Swiss-Prot 55.0 View   
11SPP1OSTP_HUMANS105QDSID S NDSDD 40.65% Swiss-Prot 55.0 View   
12SPP1OSTP_HUMANS108IDSND S DDVDD 39.70% Swiss-Prot 55.0 View   
13SPP1OSTP_HUMANS117DDTDD S HQSDE 26.66% Swiss-Prot 55.0 View   
14SPP1OSTP_HUMANS120DDSHQ S DESHH 37.61% Swiss-Prot 55.0 View   
15SPP1OSTP_HUMANS123HQSDE S HHSDE 31.33% Swiss-Prot 55.0 View   
16SPP1OSTP_HUMANS126DESHH S DESDE 37.34% Swiss-Prot 55.0 View   
17SPP1OSTP_HUMANS129HHSDE S DELVT 41.18% Swiss-Prot 55.0 View   
18SPP1OSTP_HUMANS162DGRGD S VVYGL 19.12%PKG1 HPRD:01325(in vitro)  ViewAnalyzing
19SPP1OSTP_HUMANS162DGRGD S VVYGL 19.12%CK2a2 HPRD:01325(in vitro)  ViewAnalyzing
20SPP1OSTP_HUMANS162DGRGD S VVYGL 19.12%CK2a1-rs HPRD:01325(in vitro)  ViewAnalyzing
21SPP1OSTP_HUMANS162DGRGD S VVYGL 19.12%CK2a1 HPRD:01325(in vitro)  ViewAnalyzing
22SPP1OSTP_HUMANS162DGRGD S VVYGL 19.12%PKCa HPRD:01325(in vitro)  ViewAnalyzing
23SPP1OSTP_HUMANT185QYPDA T DEDIT 47.50% Swiss-Prot 55.0 View   
24SPP1OSTP_HUMANS191DEDIT S HMESE 22.59% Swiss-Prot 55.0 View   
25SPP1OSTP_HUMANS195TSHME S EELNG 28.88% Swiss-Prot 55.0 View   
26SPP1OSTP_HUMANS215DLNAP S DWDSR 49.26% Swiss-Prot 55.0 View   
27SPP1OSTP_HUMANS219PSDWD S RGKDS 38.38% Swiss-Prot 55.0 View   
28SPP1OSTP_HUMANS224SRGKD S YETSQ 28.49% Swiss-Prot 55.0 View   
29SPP1OSTP_HUMANS228DSYET S QLDDQ 19.46% Swiss-Prot 55.0 View   
30SPP1OSTP_HUMANS234QLDDQ S AETHS 34.76% Swiss-Prot 55.0 View   
31SPP1OSTP_HUMANS254KANDE S NEHSD 50.83% Swiss-Prot 55.0 View   
32SPP1OSTP_HUMANS263SDVID S QELSK 17.90% Swiss-Prot 55.0 View   
33SPP1OSTP_HUMANS267DSQEL S KVSRE 30.20% Swiss-Prot 55.0 View   
34SPP1OSTP_HUMANS275SREFH S HEFHS 29.99% Swiss-Prot 55.0 View   
35SPP1OSTP_HUMANS280SHEFH S HEDML 33.61% Swiss-Prot 55.0 View   
36SPP1OSTP_HUMANS303LKFRI S HELDS 13.47% Swiss-Prot 55.0 View   
37SPP1OSTP_HUMANS308SHELD S ASSEV 42.55% Swiss-Prot 55.0 View   
38SPP1OSTP_HUMANS310ELDSA S SEVN 30.86% Swiss-Prot 55.0 View