Regulatory Network in Protein Phosphorylation
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Substrate: SPTBN1

Description: Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)(Beta-II spectrin) (Fodrin beta chain).

Synonyms: SPTB2

Ensembl ID: ENSG00000115306

UniprotKB/SwissProt: SPTB2_HUMAN (Q01082)

Function: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton (By similarity). Isoform 2: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
PDB:1AA2
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SPTBN1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SPTBN1SPTB2_HUMANT346LQAFN T YRTVE 14.13% HPRD:01683(in vitro;in vivo)View   
2SPTBN1SPTB2_HUMANT999LQRKL T GMERD 37.20% Swiss-Prot 55.0 (Similarity)View   
3SPTBN1SPTB2_HUMANY1805ILAAS Y ELHKF 20.13% Swiss-Prot 55.0 (Similarity)View   
4SPTBN1SPTB2_HUMANS1918KFRFF S MVRDL 17.41% Swiss-Prot 55.0 (Similarity)View   
5SPTBN1SPTB2_HUMANS2102KRRPP S PEPST 44.57% Swiss-Prot 55.0 View   
6SPTBN1SPTB2_HUMANS2102KRRPP S PEPST 44.57% Phospho.ELM 7.0View   
7SPTBN1SPTB2_HUMANS2102KRRPP S PEPST 44.57% HPRD:01683(in vivo)View   
8SPTBN1SPTB2_HUMANS2110PSTKV S EEAES 31.13%CK2a1 HPRD:01683(in vitro)  ViewAnalyzing
9SPTBN1SPTB2_HUMANS2110PSTKV S EEAES 31.13%CK2a1-rs HPRD:01683(in vitro)  ViewAnalyzing
10SPTBN1SPTB2_HUMANS2115SEEAE S QQQWD 40.09% Swiss-Prot 55.0 (Similarity)View   
11SPTBN1SPTB2_HUMANS2115SEEAE S QQQWD 40.09% HPRD:01683(in vivo)View   
12SPTBN1SPTB2_HUMANS2128KGEQV S QNGLP 20.02% Phospho.ELM 7.0View   
13SPTBN1SPTB2_HUMANS2128KGEQV S QNGLP 20.02% HPRD:01683(in vivo)View   
14SPTBN1SPTB2_HUMANS2128KGEQV S QNGLP 20.02% Swiss-Prot 55.0 View   
15SPTBN1SPTB2_HUMANS2138PAEQG S PRMAE 14.72% Phospho.ELM 7.0View   
16SPTBN1SPTB2_HUMANS2138PAEQG S PRMAE 14.72% HPRD:01683(in vivo)View   
17SPTBN1SPTB2_HUMANS2138PAEQG S PRMAE 14.72% Swiss-Prot 55.0 View   
18SPTBN1SPTB2_HUMANT2159ATEQR T SSKES 36.73%CK2a1-rs HPRD:01683(in vitro;in vivo)  ViewAnalyzing
19SPTBN1SPTB2_HUMANT2159ATEQR T SSKES 36.73%PKACa HPRD:01683(in vivo)  ViewAnalyzing
20SPTBN1SPTB2_HUMANT2159ATEQR T SSKES 36.73%CK2a1 HPRD:01683(in vitro;in vivo)  ViewAnalyzing
21SPTBN1SPTB2_HUMANS2161EQRTS S KESSP 39.57% HPRD:01683(in vivo)View   
22SPTBN1SPTB2_HUMANS2161EQRTS S KESSP 39.57% Phospho.ELM 7.0View   
23SPTBN1SPTB2_HUMANS2164TSSKE S SPIPS 45.19% Phospho.ELM 7.0View   
24SPTBN1SPTB2_HUMANS2165SSKES S PIPSP 28.13% Swiss-Prot 55.0 View   
25SPTBN1SPTB2_HUMANS2165SSKES S PIPSP 28.13% Phospho.ELM 7.0View   
26SPTBN1SPTB2_HUMANS2165SSKES S PIPSP 28.13% HPRD:01683(in vivo)View   
27SPTBN1SPTB2_HUMANS2169SSPIP S PTSDR 41.34% Swiss-Prot 55.0 View   
28SPTBN1SPTB2_HUMANS2169SSPIP S PTSDR 41.34% HPRD:01683(in vivo)View   
29SPTBN1SPTB2_HUMANS2169SSPIP S PTSDR 41.34% Phospho.ELM 7.0View   
30SPTBN1SPTB2_HUMANT2195ARTQE T PSAQM 16.84% Swiss-Prot 55.0 (Similarity)View   
31SPTBN1SPTB2_HUMANT2320ASTQS T PASSR 17.04% Phospho.ELM 7.0View