Regulatory Network in Protein Phosphorylation
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Substrate: SSRP1

Description: FACT complex subunit SSRP1 (Facilitates chromatin transcriptioncomplex subunit SSRP1) (FACT 80 kDa subunit) (FACTp80) (Chromatin-specific transcription elongation factor 80 kDa subunit) (Structure-specific recognition protein 1) (hSSRP1) (Recombination signalsequence recognition protein 1) (T160).

Synonyms: FACT80

Ensembl ID: ENSG00000149136

UniprotKB/SwissProt: SSRP1_HUMAN (Q08945)

Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SSRP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SSRP1SSRP1_HUMANY311MSGSL Y EMVSR 12.04% Swiss-Prot 55.0 View   
2SSRP1SSRP1_HUMANY441PSYDE Y ADSDE 16.89% Swiss-Prot 55.0 (Similarity)View   
3SSRP1SSRP1_HUMANS444DEYAD S DEDQH 34.43% Phospho.ELM 7.0View   
4SSRP1SSRP1_HUMANS444DEYAD S DEDQH 34.43% Swiss-Prot 55.0 View   
5SSRP1SSRP1_HUMANS444DEYAD S DEDQH 34.43% HPRD:05061(in vivo)View   
6SSRP1SSRP1_HUMANS510SNEGD S DRDEK 45.46%CK2a1-rs HPRD:05061(in vitro)  ViewAnalyzing
7SSRP1SSRP1_HUMANS510SNEGD S DRDEK 45.46%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
8SSRP1SSRP1_HUMANS510SNEGD S DRDEK 45.46%CK2_group Swiss-Prot 55.0 (Probable) ViewAnalyzing
9SSRP1SSRP1_HUMANS510SNEGD S DRDEK 45.46%CK2a1 HPRD:05061(in vitro)  ViewAnalyzing
10SSRP1SSRP1_HUMANY554RPMSA Y MLWLN 5.85% Swiss-Prot 55.0 View   
11SSRP1SSRP1_HUMANY554RPMSA Y MLWLN 5.85% Phospho.ELM 7.0View   
12SSRP1SSRP1_HUMANS561LWLNA S REKIK 39.64% Swiss-Prot 55.0 View   
13SSRP1SSRP1_HUMANS561LWLNA S REKIK 39.64% Phospho.ELM 7.0View   
14SSRP1SSRP1_HUMANS657SSRQL S ESFKS 23.90%CK2a1-rs HPRD:05061(in vitro)  ViewAnalyzing
15SSRP1SSRP1_HUMANS657SSRQL S ESFKS 23.90%CK2a1 HPRD:05061(in vitro)  ViewAnalyzing
16SSRP1SSRP1_HUMANS657SSRQL S ESFKS 23.90% Swiss-Prot 55.0 View   
17SSRP1SSRP1_HUMANS667SKEFV S SDESS 37.08% Swiss-Prot 55.0 View   
18SSRP1SSRP1_HUMANS667SKEFV S SDESS 37.08% Phospho.ELM 7.0View   
19SSRP1SSRP1_HUMANS668KEFVS S DESSS 39.84% Phospho.ELM 7.0View   
20SSRP1SSRP1_HUMANS668KEFVS S DESSS 39.84% Swiss-Prot 55.0 View   
21SSRP1SSRP1_HUMANS671VSSDE S SSGEN 34.49% Phospho.ELM 7.0View   
22SSRP1SSRP1_HUMANS671VSSDE S SSGEN 34.49% Swiss-Prot 55.0 View   
23SSRP1SSRP1_HUMANS672SSDES S SGENK 40.07% Phospho.ELM 7.0View   
24SSRP1SSRP1_HUMANS672SSDES S SGENK 40.07% Swiss-Prot 55.0 View   
25SSRP1SSRP1_HUMANS673SDESS S GENKS 60.45% Swiss-Prot 55.0 View   
26SSRP1SSRP1_HUMANS688RRSED S EEEEL 42.74%CK2a1-rs HPRD:05061(in vitro)  ViewAnalyzing
27SSRP1SSRP1_HUMANS688RRSED S EEEEL 42.74%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
28SSRP1SSRP1_HUMANS688RRSED S EEEEL 42.74%CK2a1 HPRD:05061(in vitro)  ViewAnalyzing
29SSRP1SSRP1_HUMANS688RRSED S EEEEL 42.74%CK2_group Swiss-Prot 55.0 (Probable) ViewAnalyzing