Regulatory Network in Protein Phosphorylation
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Substrate: TCF7L2

Description: Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (TCF-4) (hTCF-4).

Synonyms: TCF4

Ensembl ID: ENSG00000148737

UniprotKB/SwissProt: TF7L2_HUMAN (Q9NQB0)

Function: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1JDH
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TCF7L2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TCF7L2TF7L2_HUMANS58ETNQN S SSDSE 22.81%CK2a2 HPRD:03751(in vitro)  ViewAnalyzing
2TCF7L2TF7L2_HUMANS58ETNQN S SSDSE 22.81%CK2_group Phospho.ELM 7.0 ViewAnalyzing
3TCF7L2TF7L2_HUMANS58ETNQN S SSDSE 22.81%CK2a1-rs HPRD:03751(in vitro)  ViewAnalyzing
4TCF7L2TF7L2_HUMANS58ETNQN S SSDSE 22.81%CK2a1 HPRD:03751(in vitro)  ViewAnalyzing
5TCF7L2TF7L2_HUMANS59TNQNS S SDSEA 45.79%CK2_group Phospho.ELM 7.0 ViewAnalyzing
6TCF7L2TF7L2_HUMANS59TNQNS S SDSEA 45.79%CK2a1-rs HPRD:03751(in vitro)  ViewAnalyzing
7TCF7L2TF7L2_HUMANS59TNQNS S SDSEA 45.79%CK2a1 HPRD:03751(in vitro)  ViewAnalyzing
8TCF7L2TF7L2_HUMANS59TNQNS S SDSEA 45.79%CK2a2 HPRD:03751(in vitro)  ViewAnalyzing
9TCF7L2TF7L2_HUMANS60NQNSS S DSEAE 45.00%CK2a2 HPRD:03751(in vitro)  ViewAnalyzing
10TCF7L2TF7L2_HUMANS60NQNSS S DSEAE 45.00%CK2_group Phospho.ELM 7.0 ViewAnalyzing
11TCF7L2TF7L2_HUMANS60NQNSS S DSEAE 45.00%CK2a1-rs HPRD:03751(in vitro)  ViewAnalyzing
12TCF7L2TF7L2_HUMANS60NQNSS S DSEAE 45.00%CK2a1 HPRD:03751(in vitro)  ViewAnalyzing