|Description: Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein-associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor)(EPI).|
Synonyms: LACI, TFPI1
Ensembl ID: ENSG00000003436
UniprotKB/SwissProt: TFPI1_HUMAN (P10646)
Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted.