|Description: Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).|
Ensembl ID: ENSG00000196781
UniprotKB/SwissProt: TLE1_HUMAN (Q04724)
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Nuclear and chromatin- associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.