Regulatory Network in Protein Phosphorylation
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Substrate: TLE2

Description: Transducin-like enhancer protein 2 (ESG2).

Ensembl ID: ENSG00000065717

UniprotKB/SwissProt: TLE2_HUMAN (Q04725)

Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TLE2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TLE2TLE2_HUMANS228SGPYE S DEDKS 40.22%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
2TLE2TLE2_HUMANS249PSEPP S PATTP 37.57%CDC2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing
3TLE2TLE2_HUMANT253PSPAT T PCGKV 20.77%CDC2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing