Regulatory Network in Protein Phosphorylation
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Substrate: TLE4

Description: Transducin-like enhancer protein 4.

Synonyms: KIAA1261

Ensembl ID: ENSG00000106829

UniprotKB/SwissProt: TLE4_HUMAN (Q04727)

Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TLE4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TLE4TLE4_HUMANS250SDGEK S DDNLV 45.99%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
2TLE4TLE4_HUMANS265NEDPS S PRGSP 24.81%CDC2 Swiss-Prot 55.0 (Potential)  ViewAnalyzing