Regulatory Network in Protein Phosphorylation
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Substrate: TNF

Description: Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factorligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumornecrosis factor, membrane form; Tumor necrosis factor, soluble form].

Synonyms: TNFA, TNFSF2

Ensembl ID: ENSG00000204490

UniprotKB/SwissProt: TNFA_HUMAN (P01375)

Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TNF

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TNFTNFA_HUMANS2----M S TESMI 40.66%CK1_group Swiss-Prot 55.0  ViewAnalyzing
2TNFTNFA_HUMANS2----M S TESMI 40.66%CK2_group Phospho.ELM 7.0 ViewAnalyzing
3TNFTNFA_HUMANS2----M S TESMI 40.66%CLIK1L HPRD:01855(in vitro;in vivo)  ViewAnalyzing