Regulatory Network in Protein Phosphorylation
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Substrate: VAMP4

Description: Vesicle-associated membrane protein 4 (VAMP-4).

Ensembl ID: ENSG00000117533

UniprotKB/SwissProt: VAMP4_HUMAN (O75379)

Function: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable). Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of VAMP4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1VAMP4VAMP4_HUMANS30LLEDD S DEEED 60.28% Swiss-Prot 55.0 View   
2VAMP4VAMP4_HUMANS30LLEDD S DEEED 60.28%CK2a1-rs HPRD:06070(in vitro)  ViewAnalyzing
3VAMP4VAMP4_HUMANS30LLEDD S DEEED 60.28%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4VAMP4VAMP4_HUMANS30LLEDD S DEEED 60.28%CK2a1 HPRD:06070(in vitro)  ViewAnalyzing