Regulatory Network in Protein Phosphorylation
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Substrate: WAS

Description: Wiskott-Aldrich syndrome protein (WASp).

Synonyms: IMD2

Ensembl ID: ENSG00000015285

UniprotKB/SwissProt: WASP_HUMAN (P42768)

Function: Effector protein for Rho-type GTPases, providing a link with the Arp2/3 complex that regulates the structure and dynamics of the actin cytoskeleton. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton.
PDB:1CEE
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of WAS

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1WASWASP_HUMANY291TSKLI Y DFIED 18.42%HCK Phospho.ELM 7.0  ViewAnalyzing
2WASWASP_HUMANY291TSKLI Y DFIED 18.42%HCK HPRD:02314(in vitro;in vivo)  ViewAnalyzing
3WASWASP_HUMANY291TSKLI Y DFIED 18.42% Swiss-Prot 55.0 View   
4WASWASP_HUMANY291TSKLI Y DFIED 18.42%BTK HPRD:02314(in vitro;in vivo)  ViewAnalyzing
5WASWASP_HUMANY291TSKLI Y DFIED 18.42%BTK Phospho.ELM 7.0  ViewAnalyzing
6WASWASP_HUMANS483SRAIH S SDEGE 33.11%CK2a1 HPRD:02314(in vitro;in vivo)  ViewAnalyzing
7WASWASP_HUMANS483SRAIH S SDEGE 33.11%CK2_group Swiss-Prot 55.0  ViewAnalyzing
8WASWASP_HUMANS483SRAIH S SDEGE 33.11%CK2a2 HPRD:02314(in vitro;in vivo)  ViewAnalyzing
9WASWASP_HUMANS483SRAIH S SDEGE 33.11%CK2a1-rs HPRD:02314(in vitro;in vivo)  ViewAnalyzing
10WASWASP_HUMANS484RAIHS S DEGED 26.06%CK2a2 HPRD:02314(in vitro;in vivo)  ViewAnalyzing
11WASWASP_HUMANS484RAIHS S DEGED 26.06%CK2a1 HPRD:02314(in vitro;in vivo)  ViewAnalyzing
12WASWASP_HUMANS484RAIHS S DEGED 26.06%CK2a1-rs HPRD:02314(in vitro;in vivo)  ViewAnalyzing
13WASWASP_HUMANS484RAIHS S DEGED 26.06%CK2_group Swiss-Prot 55.0  ViewAnalyzing
14WASWASP_HUMANS484RAIHS S DEGED 26.06%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing