Regulatory Network in Protein Phosphorylation
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Substrate: XRCC1

Description: DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

Ensembl ID: ENSG00000073050

UniprotKB/SwissProt: XRCC1_HUMAN (P18887)

Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Accumulates at sites of DNA damage.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of XRCC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1XRCC1XRCC1_HUMANS266PPAQL S PSVPK 11.75% Swiss-Prot 55.0 View   
2XRCC1XRCC1_HUMANS268AQLSP S VPKRP 47.91% Phospho.ELM 7.0View   
3XRCC1XRCC1_HUMANS371NTPKY S QVLGL 21.68%DNAPK Swiss-Prot 55.0   ViewAnalyzing
4XRCC1XRCC1_HUMANS408MAGPG S SSEED 33.55% Phospho.ELM 7.0View   
5XRCC1XRCC1_HUMANS408MAGPG S SSEED 33.55% Swiss-Prot 55.0 View   
6XRCC1XRCC1_HUMANS409AGPGS S SEEDE 47.92% Swiss-Prot 55.0 View   
7XRCC1XRCC1_HUMANS409AGPGS S SEEDE 47.92% Phospho.ELM 7.0View   
8XRCC1XRCC1_HUMANS410GPGSS S EEDEA 46.86% Swiss-Prot 55.0