Regulatory Network in Protein Phosphorylation
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Substrate: PTPN1

Description: Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B).

Synonyms: PTP1B

Ensembl ID: ENSG00000196396

UniprotKB/SwissProt: PTN1_HUMAN (P18031)

Function: May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
PDB:1A5Y
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PTPN1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PTPN1PTN1_HUMANY20SWAAI Y QDIRH 8.73% Swiss-Prot 55.0 View   
2PTPN1PTN1_HUMANY20SWAAI Y QDIRH 8.73% Phospho.ELM 7.0View   
3PTPN1PTN1_HUMANS50RYRDV S PFDHS 24.92%CLK2 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
4PTPN1PTN1_HUMANS50RYRDV S PFDHS 24.92%CLK1 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
5PTPN1PTN1_HUMANS50RYRDV S PFDHS 24.92%CLK1 Phospho.ELM 7.0  ViewAnalyzing
6PTPN1PTN1_HUMANS50RYRDV S PFDHS 24.92%AKT1 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
7PTPN1PTN1_HUMANS50RYRDV S PFDHS 24.92%AKT_group Phospho.ELM 7.0 ViewAnalyzing
8PTPN1PTN1_HUMANS50RYRDV S PFDHS 24.92%AKT1(PKB) Swiss-Prot 55.0  ViewAnalyzing
9PTPN1PTN1_HUMANY66QEDND Y INASL 11.43%InsR Phospho.ELM 7.0  ViewAnalyzing
10PTPN1PTN1_HUMANY66QEDND Y INASL 11.43%INSR HPRD:01477(in vitro;in vivo)  ViewAnalyzing
11PTPN1PTN1_HUMANY66QEDND Y INASL 11.43%EGFR Phospho.ELM 7.0  ViewAnalyzing
12PTPN1PTN1_HUMANY66QEDND Y INASL 11.43%EGFR HPRD:01477(in vitro;in vivo)  ViewAnalyzing
13PTPN1PTN1_HUMANY152EDIKS Y YTVRQ 9.73%INSR HPRD:01477(in vitro;in vivo)  ViewAnalyzing
14PTPN1PTN1_HUMANY152EDIKS Y YTVRQ 9.73%InsR Phospho.ELM 7.0  ViewAnalyzing
15PTPN1PTN1_HUMANY153DIKSY Y TVRQL 13.07%InsR Phospho.ELM 7.0  ViewAnalyzing
16PTPN1PTN1_HUMANY153DIKSY Y TVRQL 13.07%INSR HPRD:01477(in vitro;in vivo)  ViewAnalyzing
17PTPN1PTN1_HUMANS242KRKDP S SVDIK 53.80%CLK1 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
18PTPN1PTN1_HUMANS242KRKDP S SVDIK 53.80%CLK2 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
19PTPN1PTN1_HUMANS243RKDPS S VDIKK 29.24%CLK2 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
20PTPN1PTN1_HUMANS243RKDPS S VDIKK 29.24%CLK1 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
21PTPN1PTN1_HUMANS295QWKEL S HEDLE 26.39% Swiss-Prot 55.0 View   
22PTPN1PTN1_HUMANS352KEEKG S PLNAA 36.96%CK2a2 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
23PTPN1PTN1_HUMANS352KEEKG S PLNAA 36.96% Swiss-Prot 55.0 View   
24PTPN1PTN1_HUMANS352KEEKG S PLNAA 36.96% Phospho.ELM 7.0View   
25PTPN1PTN1_HUMANS352KEEKG S PLNAA 36.96%CK2a1-rs HPRD:01477(in vitro;in vivo)  ViewAnalyzing
26PTPN1PTN1_HUMANS352KEEKG S PLNAA 36.96%CK2a1 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
27PTPN1PTN1_HUMANS378RVVGG S LRGAQ 14.68%PKC_group Swiss-Prot 55.0  ViewAnalyzing
28PTPN1PTN1_HUMANS378RVVGG S LRGAQ 14.68%CK2a1-rs HPRD:01477(in vitro;in vivo)  ViewAnalyzing
29PTPN1PTN1_HUMANS378RVVGG S LRGAQ 14.68%PKC_group Phospho.ELM 7.0 ViewAnalyzing
30PTPN1PTN1_HUMANS378RVVGG S LRGAQ 14.68%CK2a2 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
31PTPN1PTN1_HUMANS378RVVGG S LRGAQ 14.68%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
32PTPN1PTN1_HUMANS378RVVGG S LRGAQ 14.68%CK2a1 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
33PTPN1PTN1_HUMANS386GAQAA S PAKGE 28.53%CDK_group Phospho.ELM 7.0 ViewAnalyzing
34PTPN1PTN1_HUMANS386GAQAA S PAKGE 28.53%CDC2 Swiss-Prot 55.0   ViewAnalyzing
35PTPN1PTN1_HUMANS386GAQAA S PAKGE 28.53%CK2a2 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
36PTPN1PTN1_HUMANS386GAQAA S PAKGE 28.53%CDC2 HPRD:01477(in vitro)  ViewAnalyzing
37PTPN1PTN1_HUMANS386GAQAA S PAKGE 28.53%CK2a1-rs HPRD:01477(in vitro;in vivo)  ViewAnalyzing
38PTPN1PTN1_HUMANS386GAQAA S PAKGE 28.53%CK2a1 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
39PTPN1PTN1_HUMANS386GAQAA S PAKGE 28.53%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
40PTPN1PTN1_HUMANS393AKGEP S LPEKD 52.86% Swiss-Prot 55.0 (Similarity)View