Regulatory Network in Protein Phosphorylation
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Substrate: PTPN1

Description: Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B).

Synonyms: PTP1B

Ensembl ID: ENSG00000196396

UniprotKB/SwissProt: PTN1_HUMAN (P18031)

Function: May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
PDB:1A5Y
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PTPN1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PTPN1PTN1_HUMANY20SWAAI Y QDIRH 8.73% Swiss-Prot 55.0 View   
2PTPN1PTN1_HUMANY20SWAAI Y QDIRH 8.73% Phospho.ELM 7.0View   
3PTPN1PTN1_HUMANS50RYRDV S PFDHS 24.92%CLK2 HPRD:01477(in vitro;in vivo)  ViewAnalyzing
4PTPN1PTN1_HUMAN