|Description: LIM domain kinase 1 (EC 220.127.116.11) (LIMK-1).|
Ensembl ID: ENSG00000106683
UniprotKB/SwissProt: LIMK1_HUMAN (P53667)
Function: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.