Regulatory Network in Protein Phosphorylation
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Substrate: PPP1R12A

Description: Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit).

Synonyms: MBS, MYPT1

Ensembl ID: ENSG00000058272

UniprotKB/SwissProt: MYPT1_HUMAN (O14974)

Function: Regulates myosin phosphatase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=Along actomyosin filaments and stress fibers.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PPP1R12A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PPP1R12AMYPT1_HUMANS422TATKI S PKEEE 31.32% Swiss-Prot 55.0 View   
2PPP1R12AMYPT1_HUMANS422TATKI S PKEEE 31.32% Phospho.ELM 7.0View   
3PPP1R12AMYPT1_HUMANT443LGLRK T GSYGA 25.56% Swiss-Prot 55.0 (Similarity)View   
4PPP1R12AMYPT1_HUMANS445LRKTG S YGALA 26.14% Swiss-Prot 55.0 View   
5PPP1R12AMYPT1_HUMANY446RKTGS Y GALAE 14.04% HPRD:03606(in vivo)View   
6PPP1R12AMYPT1_HUMANS507PRRLA S TSDIE 32.79% Swiss-Prot 55.0 View   
7PPP1R12AMYPT1_HUMANT508RRLAS T SDIEE 25.47% Swiss-Prot 55.0 (Similarity)View   
8PPP1R12AMYPT1_HUMANS509RLAST S DIEEK 33.81% Swiss-Prot 55.0 (Similarity)View   
9PPP1R12AMYPT1_HUMANS566DLISS S VPSTT 31.12% Swiss-Prot 55.0 (Similarity)View   
10PPP1R12AMYPT1_HUMANS569SSSVP S TTSTP 42.01% Swiss-Prot 55.0 (Similarity)View   
11PPP1R12AMYPT1_HUMANT696QSRRS T QGVTL 27.77%ROCK1 Phospho.ELM 7.0  ViewAnalyzing
12PPP1R12AMYPT1_HUMANT696QSRRS T QGVTL 27.77%ROCK1 HPRD:03606(in vitro)  ViewAnalyzing
13PPP1R12AMYPT1_HUMANT696QSRRS T QGVTL 27.77%DMPK1 HPRD:03606(in vitro)  ViewAnalyzing
14PPP1R12AMYPT1_HUMANT696QSRRS T QGVTL 27.77%ILK HPRD:03606(in vitro)  ViewAnalyzing
15PPP1R12AMYPT1_HUMANT696QSRRS T QGVTL 27.77%ROCK1 Swiss-Prot 55.0   ViewAnalyzing
16PPP1R12AMYPT1_HUMANT696QSRRS T QGVTL 27.77%MRCKa(CDC42BP) Swiss-Prot 55.0  ViewAnalyzing
17PPP1R12AMYPT1_HUMANS852REKRR S TGVSF 33.28%ROCK1 Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
18PPP1R12AMYPT1_HUMANT853EKRRS T GVSFW 39.53%ROCK2 HPRD:03606(in vitro)  ViewAnalyzing
19PPP1R12AMYPT1_HUMANT853EKRRS T GVSFW 39.53%ROCK1 HPRD:03606(in vitro)  ViewAnalyzing
20PPP1R12AMYPT1_HUMANS871EQEQQ S DTEEG 46.31% Phospho.ELM 7.0View   
21PPP1R12AMYPT1_HUMANS871EQEQQ S DTEEG 46.31% Swiss-Prot 55.0 (Similarity)View   
22PPP1R12AMYPT1_HUMANY890DSISR Y ETSST 19.44% Phospho.ELM 7.0View   
23PPP1R12AMYPT1_HUMANY890DSISR Y ETSST 19.44% HPRD:03606(in vitro)View   
24PPP1R12AMYPT1_HUMANY890DSISR Y ETSST 19.44% Swiss-Prot 55.0 View   
25PPP1R12AMYPT1_HUMANY901SAGDR Y DSLLG 18.02% HPRD:03606(in vitro)View   
26PPP1R12AMYPT1_HUMANY901SAGDR Y DSLLG 18.02% Phospho.ELM 7.0View   
27PPP1R12AMYPT1_HUMANY901SAGDR Y DSLLG 18.02% Swiss-Prot 55.0 View   
28PPP1R12AMYPT1_HUMANS910LGRSG S YSYLE 16.50% Swiss-Prot 55.0 (Similarity)View   
29PPP1R12AMYPT1_HUMANY911GRSGS Y SYLEE 12.59% Phospho.ELM 7.0View   
30PPP1R12AMYPT1_HUMANY911GRSGS Y SYLEE 12.59% HPRD:03606(in vitro)View   
31PPP1R12AMYPT1_HUMANY911GRSGS Y SYLEE 12.59% Swiss-Prot 55.0 View