Regulatory Network in Protein Phosphorylation
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Substrate: LIMK1

Description: LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

Synonyms: LIMK

Ensembl ID: ENSG00000106683

UniprotKB/SwissProt: LIMK1_HUMAN (P53667)

Function: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of LIMK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1LIMK1LIMK1_HUMANS298VLRSC S IDRSP 28.86% Swiss-Prot 55.0 View   
2LIMK1LIMK1_HUMANS298VLRSC S IDRSP 28.86% Phospho.ELM 7.0View   
3LIMK1LIMK1_HUMANS310AGSLG S PASQR 23.68% Swiss-Prot 55.0 View   
4LIMK1LIMK1_HUMANS310AGSLG S PASQR 23.68% Phospho.ELM 7.0View   
5LIMK1LIMK1_HUMANT508RKKRY T VVGNP 16.85%PAK1 Phospho.ELM 7.0  ViewAnalyzing
6LIMK1LIMK1_HUMANT508RKKRY T VVGNP 16.85%ROCK_group Phospho.ELM 7.0 ViewAnalyzing
7LIMK1LIMK1_HUMANT508RKKRY T VVGNP 16.85%MRCKa HPRD:03210(in vitro;in vivo)  ViewAnalyzing
8LIMK1LIMK1_HUMANT508RKKRY T VVGNP 16.85%MRCKa Phospho.ELM 7.0  ViewAnalyzing
9LIMK1LIMK1_HUMANT508RKKRY T VVGNP 16.85%ROCK1 HPRD:03210(in vitro;in vivo)  ViewAnalyzing
10LIMK1LIMK1_HUMANT508RKKRY T VVGNP 16.85%ROCK1 Swiss-Prot 55.0   ViewAnalyzing
11LIMK1LIMK1_HUMANT508RKKRY T VVGNP 16.85%PAK1 HPRD:03210(in vitro;in vivo)  ViewAnalyzing