Regulatory Network in Protein Phosphorylation
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Substrate: LIMK2

Description: LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

Ensembl ID: ENSG00000182541

UniprotKB/SwissProt: LIMK2_HUMAN (P53671)

Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus, and isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.
PDB:1X6A
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of LIMK2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1LIMK2LIMK2_HUMANS283TLRRR S LRRSN 25.15%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
2LIMK2LIMK2_HUMANS289LRRSN S ISKSP 29.50% Swiss-Prot 55.0 View   
3LIMK2LIMK2_HUMANS289LRRSN S ISKSP 29.50% Phospho.ELM 7.0View   
4LIMK2LIMK2_HUMANS291RSNSI S KSPGP 27.23% Phospho.ELM 7.0View   
5LIMK2LIMK2_HUMANS291RSNSI S KSPGP 27.23% Swiss-Prot 55.0 View   
6LIMK2LIMK2_HUMANS293NSISK S PGPSS 28.44% Phospho.ELM 7.0View   
7LIMK2LIMK2_HUMANS293NSISK S PGPSS 28.44% Swiss-Prot 55.0 View   
8LIMK2LIMK2_HUMANT505RKKRY T VVGNP 16.85% Swiss-Prot 55.0 View   
9LIMK2LIMK2_HUMANT505RKKRY T VVGNP 16.85%MRCKa HPRD:03585(in vitro)  ViewAnalyzing
10LIMK2LIMK2_HUMANT505RKKRY T VVGNP 16.85%MRCKa Phospho.ELM 7.0  ViewAnalyzing
11LIMK2LIMK2_HUMANT505RKKRY T VVGNP 16.85%ROCK1 HPRD:03585(in vitro;in vivo)  ViewAnalyzing
12LIMK2LIMK2_HUMANT505RKKRY T VVGNP 16.85%ROCK_group Phospho.ELM 7.0 ViewAnalyzing
13LIMK2LIMK2_HUMANT526KSYDE T VDIFS 22.15%MRCKa HPRD:03585(in vitro)  ViewAnalyzing
14LIMK2LIMK2_HUMANT526KSYDE T VDIFS 22.15%ROCK1 HPRD:03585(in vitro;in vivo)  ViewAnalyzing