Regulatory Network in Protein Phosphorylation
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Substrate: CDC20

Description: Cell division cycle protein 20 homolog (p55CDC).

Ensembl ID: ENSG00000117399

UniprotKB/SwissProt: CDC20_HUMAN (Q12834)

Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDC20

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDC20CDC20_HUMANS41AGPAP S PMRAA 33.17%BUB1 HPRD:04686(in vitro;in vivo)  ViewAnalyzing
2CDC20CDC20_HUMANT70SKVQT T PSKPG 14.42% Swiss-Prot 55.0 View   
3CDC20CDC20_HUMANT70SKVQT T PSKPG 14.42% Phospho.ELM 7.0View   
4CDC20CDC20_HUMANS72VQTTP S KPGGD 49.76%BUB1 HPRD:04686(in vitro;in vivo)  ViewAnalyzing
5CDC20CDC20_HUMANS92QMEVA S FLLSK 22.92%BUB1 HPRD:04686(in vitro;in vivo)  ViewAnalyzing
6CDC20CDC20_HUMANT106PENSQ T PTKKE 32.52% Swiss-Prot 55.0 View   
7CDC20CDC20_HUMANT106PENSQ T PTKKE 32.52% Phospho.ELM 7.0View   
8CDC20CDC20_HUMANS153LKVLY S QKATP 22.50%BUB1 HPRD:04686(in vitro;in vivo)  ViewAnalyzing
9CDC20CDC20_HUMANT157YSQKA T PGSSR 34.91%BUB1 HPRD:04686(in vitro;in vivo)  ViewAnalyzing
10CDC20CDC20_HUMANS161ATPGS S RKTCR 43.65%BUB1 HPRD:04686(in vitro;in vivo)  ViewAnalyzing