Regulatory Network in Protein Phosphorylation
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Substrate: TP53

Description: Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13).

Synonyms: P53

Ensembl ID: ENSG00000141510

UniprotKB/SwissProt: P53_HUMAN (P04637)

Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Interaction with BANP promotes nuclear localization.
PDB:1A1U
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TP53

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TP53P53_HUMANS6MEEPQ S DPSVE 63.30%CK1a HPRD:01859(in vitro)  ViewAnalyzing
2TP53P53_HUMANS9PQSDP S VEPPL 44.07%ATM HPRD:01859(in vitro;in vivo)  ViewAnalyzing
3TP53P53_HUMANS9PQSDP S VEPPL 44.07%CK1a HPRD:01859(in vitro;in vivo)  ViewAnalyzing
4TP53P53_HUMANS9PQSDP S VEPPL 44.07% Phospho.ELM 7.0View   
5TP53P53_HUMANS15VEPPL S QETFS 31.57%ATR HPRD:01859(in vitro;in vivo)  ViewAnalyzing
6TP53P53_HUMANS15VEPPL S QETFS 31.57%ATM HPRD:01859(in vivo)  ViewAnalyzing
7TP53P53_HUMANS15VEPPL S QETFS 31.57%ATM Phospho.ELM 7.0  ViewAnalyzing
8TP53P53_HUMANS15VEPPL S QETFS 31.57%CHK1 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
9TP53P53_HUMANS15VEPPL S QETFS 31.57%PRPK Swiss-Prot 55.0   ViewAnalyzing
10TP53P53_HUMANS15VEPPL S QETFS 31.57%Erk2 HPRD:01859(in vitro)  ViewAnalyzing
11TP53P53_HUMANS15VEPPL S QETFS 31.57% HPRD:01859(in vivo)View   
12TP53P53_HUMANS15VEPPL S QETFS 31.57%RSK2 Phospho.ELM 7.0  ViewAnalyzing
13TP53P53_HUMANS15VEPPL S QETFS 31.57%DNAPK HPRD:01859(in vitro;in vivo)  ViewAnalyzing
14TP53P53_HUMANS15VEPPL S QETFS 31.57%DNAPK Phospho.ELM 7.0  ViewAnalyzing
15TP53P53_HUMANT18PLSQE T FSDLW 22.32%VRK1 Swiss-Prot 55.0   ViewAnalyzing
16TP53P53_HUMANT18PLSQE T FSDLW 22.32%ATR HPRD:01859(in vitro;in vivo)  ViewAnalyzing
17TP53P53_HUMANT18PLSQE T FSDLW 22.32%CK1_group Phospho.ELM 7.0 ViewAnalyzing
18TP53P53_HUMANT18PLSQE T FSDLW 22.32%CK1d HPRD:01859(in vitro)  ViewAnalyzing
19TP53P53_HUMANT18PLSQE T FSDLW 22.32%P67870(Casein kinase II, beta) HPRD:01859(in vitro;in vivo) ViewAnalyzing
20TP53P53_HUMANT18PLSQE T FSDLW 22.32%VRK1 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
21TP53P53_HUMANT18PLSQE T FSDLW 22.32%CK2a1 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
22TP53P53_HUMANT18PLSQE T FSDLW 22.32%CK2a1-rs HPRD:01859(in vitro;in vivo)  ViewAnalyzing
23TP53P53_HUMANT18PLSQE T FSDLW 22.32%DNAPK HPRD:01859(in vitro;in vivo)  ViewAnalyzing
24TP53P53_HUMANS20SQETF S DLWKL 38.93%CHK2 Phospho.ELM 7.0  ViewAnalyzing
25TP53P53_HUMANS20SQETF S DLWKL 38.93%ATM HPRD:01859(in vitro;in vivo)  ViewAnalyzing
26TP53P53_HUMANS20SQETF S DLWKL 38.93%PLK3 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
27TP53P53_HUMANS20SQETF S DLWKL 38.93%DNAPK HPRD:01859(in vitro;in vivo)  ViewAnalyzing
28TP53P53_HUMANS20SQETF S DLWKL 38.93%ATR HPRD:01859(in vitro;in vivo)  ViewAnalyzing
29TP53P53_HUMANS20SQETF S DLWKL 38.93%CHK1 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
30TP53P53_HUMANS33ENNVL S PLPSQ 21.80%DNAPK HPRD:01859(in vitro)  ViewAnalyzing
31TP53P53_HUMANS33ENNVL S PLPSQ 21.80%GSK3B HPRD:01859(in vitro;in vivo)  ViewAnalyzing
32TP53P53_HUMANS33ENNVL S PLPSQ 21.80%CDK7 Phospho.ELM 7.0  ViewAnalyzing
33TP53P53_HUMANS33ENNVL S PLPSQ 21.80%CDK5 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
34TP53P53_HUMANS33ENNVL S PLPSQ 21.80%CDK9 HPRD:01859(in vitro)  ViewAnalyzing
35TP53P53_HUMANS33ENNVL S PLPSQ 21.80%CDK_group Phospho.ELM 7.0 ViewAnalyzing
36TP53P53_HUMANS33ENNVL S PLPSQ 21.80%GSK_group Phospho.ELM 7.0 ViewAnalyzing
37TP53P53_HUMANS33ENNVL S PLPSQ 21.80%ATM HPRD:01859(in vitro)  ViewAnalyzing
38TP53P53_HUMANS37LSPLP S QAMDD 37.95%ATR HPRD:01859(in vitro;in vivo)  ViewAnalyzing
39TP53P53_HUMANS37LSPLP S QAMDD 37.95%DNAPK Phospho.ELM 7.0  ViewAnalyzing
40TP53P53_HUMANS37LSPLP S QAMDD 37.95%CHK1 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
41TP53P53_HUMANS37LSPLP S QAMDD 37.95%ATM HPRD:01859(in vitro;in vivo)  ViewAnalyzing
42TP53P53_HUMANS37LSPLP S QAMDD 37.95%DNAPK HPRD:01859(in vitro;in vivo)  ViewAnalyzing
43TP53P53_HUMANS46DDLML S PDDIE 16.59%ATM HPRD:01859(in vivo)  ViewAnalyzing
44TP53P53_HUMANS46DDLML S PDDIE 16.59%HIPK2 Swiss-Prot 55.0   ViewAnalyzing
45TP53P53_HUMANS46DDLML S PDDIE 16.59%HIPK2 Phospho.ELM 7.0  ViewAnalyzing
46TP53P53_HUMANS46DDLML S PDDIE 16.59%HIPK2 HPRD:01859(in vivo)  ViewAnalyzing
47TP53P53_HUMANT55IEQWF T EDPGP 36.20%Erk2 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
48TP53P53_HUMANT55IEQWF T EDPGP 36.20%MAPK_group Phospho.ELM 7.0 ViewAnalyzing
49TP53P53_HUMANT55IEQWF T EDPGP 36.20%TAF1 Swiss-Prot 55.0   ViewAnalyzing
50TP53P53_HUMANT81APAAP T PAAPA 22.34%JNK1 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
51TP53P53_HUMANS99SSSVP S QKTYQ 42.00% Swiss-Prot 55.0 View   
52TP53P53_HUMANT155TPPPG T RVRAM 31.59%CK2a1 HPRD:01859(in vitro)  ViewAnalyzing
53TP53P53_HUMANT155TPPPG T RVRAM 31.59%CK2a1-rs HPRD:01859(in vitro)  ViewAnalyzing
54TP53P53_HUMANS215NTFRH S VVVPY 16.61%AurA Phospho.ELM 7.0  ViewAnalyzing
55TP53P53_HUMANS315NNTSS S PQPKK 27.59%CDK_group Phospho.ELM 7.0 ViewAnalyzing
56TP53P53_HUMANS315NNTSS S PQPKK 27.59%CDK5 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
57TP53P53_HUMANS315NNTSS S PQPKK 27.59%CDK2 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
58TP53P53_HUMANS315NNTSS S PQPKK 27.59%CDC2 Swiss-Prot 55.0   ViewAnalyzing
59TP53P53_HUMANS315NNTSS S PQPKK 27.59%CDK9 HPRD:01859(in vitro)  ViewAnalyzing
60TP53P53_HUMANS315NNTSS S PQPKK 27.59%AurA Phospho.ELM 7.0  ViewAnalyzing
61TP53P53_HUMANS366GSRAH S SHLKS 20.61% HPRD:01859(in vitro)View   
62TP53P53_HUMANS371SSHLK S KKGQS 46.06%CDK7 Phospho.ELM 7.0  ViewAnalyzing
63TP53P53_HUMANS371SSHLK S KKGQS 46.06%PKCa HPRD:01859(in vitro)  ViewAnalyzing
64TP53P53_HUMANS376SKKGQ S TSRHK 36.70%CDK7 Phospho.ELM 7.0  ViewAnalyzing
65TP53P53_HUMANS378KGQST S RHKKL 37.32%CDK7 Phospho.ELM 7.0  ViewAnalyzing
66TP53P53_HUMANS378KGQST S RHKKL 37.32%PKCa HPRD:01859(in vitro)  ViewAnalyzing
67TP53P53_HUMANS392TEGPD S48.64%CDK2 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
68TP53P53_HUMANS392TEGPD S48.64%PKR(EIF2AK2) Phospho.ELM 7.0 ViewAnalyzing
69TP53P53_HUMANS392TEGPD S48.64%CK2_group Phospho.ELM 7.0 ViewAnalyzing
70TP53P53_HUMANS392TEGPD S48.64%p38a HPRD:01859(in vitro;in vivo)  ViewAnalyzing
71TP53P53_HUMANS392TEGPD S48.64%CDK9 HPRD:01859(in vitro)  ViewAnalyzing
72TP53P53_HUMANS392TEGPD S48.64%CDK7 Phospho.ELM 7.0  ViewAnalyzing
73TP53P53_HUMANS392TEGPD S48.64%CK2_group Swiss-Prot 55.0  ViewAnalyzing
74TP53P53_HUMANS392TEGPD S48.64%CK2a1-rs HPRD:01859(in vitro;in vivo)  ViewAnalyzing
75TP53P53_HUMANS392TEGPD S48.64%CK2a1 HPRD:01859(in vitro;in vivo)  ViewAnalyzing
76TP53P53_HUMANS392TEGPD S48.64%PKR HPRD:01859(in vitro;in vivo)  ViewAnalyzing