Regulatory Network in Protein Phosphorylation
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Substrate: EIF2S1

Description: Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A).

Synonyms: EIF2A

Ensembl ID: ENSG00000134001

UniprotKB/SwissProt: IF2A_HUMAN (P05198)

Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1KL9
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EIF2S1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EIF2S1IF2A_HUMANS49GMILL S ELSRR 32.80%HRI Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
2EIF2S1IF2A_HUMANS49GMILL S ELSRR 32.80%PKR(EIF2AK2) Phospho.ELM 7.0 ViewAnalyzing
3EIF2S1IF2A_HUMANS49GMILL S ELSRR 32.80%HRI Phospho.ELM 7.0  ViewAnalyzing
4EIF2S1IF2A_HUMANS49GMILL S ELSRR 32.80% HPRD:04881(in vitro)View   
5EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%PKR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
6EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%PKR HPRD:04881(in vivo)  ViewAnalyzing
7EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%EIF2AK3 Swiss-Prot 55.0 (Similarity) ViewAnalyzing
8EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%PKR(EIF2AK2) Phospho.ELM 7.0 ViewAnalyzing
9EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%GCN2 Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
10EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%HRI HPRD:04881(in vivo)  ViewAnalyzing
11EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%HRI Phospho.ELM 7.0  ViewAnalyzing
12EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%HRI Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
13EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%PKCd HPRD:04881(in vivo)  ViewAnalyzing
14EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%O43422(PRKRI repressor) HPRD:04881(in vivo) ViewAnalyzing
15EIF2S1IF2A_HUMANS52LLSEL S RRRIR 21.49%PEK HPRD:04881(in vitro;in vivo)  ViewAnalyzing