Regulatory Network in Protein Phosphorylation
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Substrate: EIF2S1

Description: Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A).

Synonyms: EIF2A

Ensembl ID: ENSG00000134001

UniprotKB/SwissProt: IF2A_HUMAN (P05198)

Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1KL9