Regulatory Network in Protein Phosphorylation
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Substrate: MAP3K14

Description: Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK)(HsNIK).

Synonyms: NIK

Ensembl ID: ENSG00000006062

UniprotKB/SwissProt: M3K14_HUMAN (Q99558)

Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MAP3K14

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MAP3K14M3K14_HUMANT559DYIPG T ETHMA 32.15%COT HPRD:05230(in vitro)  ViewAnalyzing
2MAP3K14M3K14_HUMANT559DYIPG T ETHMA 32.15%MAP3K8 Phospho.ELM 7.0  ViewAnalyzing
3MAP3K14M3K14_HUMANT559DYIPG T ETHMA 32.15%MAP3K8 HPRD:05230(in vitro)  ViewAnalyzing