|Description: Inhibitor of nuclear factor kappa-B kinase subunit alpha(EC 188.8.131.52) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA).|
Synonyms: IKKA, TCF16
Ensembl ID: ENSG00000213341
UniprotKB/SwissProt: IKKA_HUMAN (O15111)
Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B- regulated promoters during inflammatory responses triggered by cytokines.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.