Regulatory Network in Protein Phosphorylation
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Substrate: CHUK

Description: Inhibitor of nuclear factor kappa-B kinase subunit alpha(EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA).

Synonyms: IKKA, TCF16

Ensembl ID: ENSG00000213341

UniprotKB/SwissProt: IKKA_HUMAN (O15111)

Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B- regulated promoters during inflammatory responses triggered by cytokines.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CHUK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CHUKIKKA_HUMANT23RERLG T GGFGN 38.43%AKT1(PKB) Swiss-Prot 55.0  ViewAnalyzing
2CHUKIKKA_HUMANT23RERLG T GGFGN 38.43%AKT1 HPRD:02811(in vitro;in vivo)  ViewAnalyzing
3CHUKIKKA_HUMANT23RERLG T GGFGN 38.43%AKT2 HPRD:02811(in vitro;in vivo)  ViewAnalyzing
4CHUKIKKA_HUMANT23RERLG T GGFGN 38.43%AKT_group Phospho.ELM 7.0 ViewAnalyzing
5CHUKIKKA_HUMANS176DVDQG S LCTSF 18.03%NIK(MAP3K14) Swiss-Prot 55.0  ViewAnalyzing
6CHUKIKKA_HUMANS176DVDQG S LCTSF 18.03%PKCt HPRD:02811(in vitro;in vivo)  ViewAnalyzing
7CHUKIKKA_HUMANS176DVDQG S LCTSF 18.03%NIK HPRD:02811(in vitro)  ViewAnalyzing
8CHUKIKKA_HUMANS180GSLCT S FVGTL 19.55%NIK HPRD:02811(in vitro)  ViewAnalyzing
9CHUKIKKA_HUMANS180GSLCT S FVGTL 19.55%PKCt HPRD:02811(in vitro;in vivo)  ViewAnalyzing