Regulatory Network in Protein Phosphorylation
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Substrate: IKBKB

Description: Inhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10)(I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

Synonyms: IKKB

Ensembl ID: ENSG00000104365

UniprotKB/SwissProt: IKKB_HUMAN (O14920)

Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3 (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of IKBKB

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1IKBKBIKKB_HUMANT23KERLG T GGFGN 38.43% Swiss-Prot 55.0 (Similarity)View   
2IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%IKKa HPRD:04462(in vitro;in vivo)  ViewAnalyzing
3IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%PKCt HPRD:04462(in vitro;in vivo)  ViewAnalyzing
4IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%PKCz HPRD:04462(in vitro)  ViewAnalyzing
5IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%NIK HPRD:04462(in vitro)  ViewAnalyzing
6IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03% Swiss-Prot 55.0 View   
7IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%TAK1 HPRD:04462(in vitro)  ViewAnalyzing
8IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%IKK_group Phospho.ELM 7.0 ViewAnalyzing
9IKBKBIKKB_HUMANS181GSLCT S FVGTL 19.55%IKK_group Phospho.ELM 7.0 ViewAnalyzing
10IKBKBIKKB_HUMANS181GSLCT S FVGTL 19.55% Swiss-Prot 55.0 View   
11IKBKBIKKB_HUMANS181GSLCT S FVGTL 19.55%PKCt HPRD:04462(in vitro;in vivo)  ViewAnalyzing
12IKBKBIKKB_HUMANS181GSLCT S FVGTL 19.55%IKKa HPRD:04462(in vitro;in vivo)  ViewAnalyzing
13IKBKBIKKB_HUMANS181GSLCT S FVGTL 19.55%TAK1 HPRD:04462(in vitro)  ViewAnalyzing
14IKBKBIKKB_HUMANS181GSLCT S FVGTL 19.55%PKCz HPRD:04462(in vitro)  ViewAnalyzing
15IKBKBIKKB_HUMANS181GSLCT S FVGTL 19.55%NIK HPRD:04462(in vitro)  ViewAnalyzing
16IKBKBIKKB_HUMANS670VRGPV S GSPDS 36.37%IKKb HPRD:04462(in vitro)  ViewAnalyzing
17IKBKBIKKB_HUMANS670VRGPV S GSPDS 36.37%IKK_group Phospho.ELM 7.0 ViewAnalyzing
18IKBKBIKKB_HUMANS670VRGPV S GSPDS 36.37%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
19IKBKBIKKB_HUMANS672GPVSG S PDSMN 20.30%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
20IKBKBIKKB_HUMANS672GPVSG S PDSMN 20.30%IKKb HPRD:04462(in vitro)  ViewAnalyzing
21IKBKBIKKB_HUMANS672GPVSG S PDSMN 20.30%IKK_group Phospho.ELM 7.0 ViewAnalyzing
22IKBKBIKKB_HUMANS675SGSPD S MNASR 19.81%IKK_group Phospho.ELM 7.0 ViewAnalyzing
23IKBKBIKKB_HUMANS675SGSPD S MNASR 19.81%IKKb HPRD:04462(in vitro)  ViewAnalyzing
24IKBKBIKKB_HUMANS675SGSPD S MNASR 19.81%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
25IKBKBIKKB_HUMANS679DSMNA S RLSQP 28.84%IKKb HPRD:04462(in vitro)  ViewAnalyzing
26IKBKBIKKB_HUMANS682NASRL S QPGQL 32.97%IKK_group Phospho.ELM 7.0 ViewAnalyzing
27IKBKBIKKB_HUMANS682NASRL S QPGQL 32.97%IKKb HPRD:04462(in vitro)  ViewAnalyzing
28IKBKBIKKB_HUMANS682NASRL S QPGQL 32.97%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
29IKBKBIKKB_HUMANS689PGQLM S QPSTA 47.75%IKKb HPRD:04462(in vitro)  ViewAnalyzing
30IKBKBIKKB_HUMANS689PGQLM S QPSTA 47.75%IKK_group Phospho.ELM 7.0 ViewAnalyzing
31IKBKBIKKB_HUMANS689PGQLM S QPSTA 47.75%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
32IKBKBIKKB_HUMANS692LMSQP S TASNS 29.03%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
33IKBKBIKKB_HUMANS692LMSQP S TASNS 29.03%IKKb HPRD:04462(in vitro)  ViewAnalyzing
34IKBKBIKKB_HUMANS692LMSQP S TASNS 29.03%IKK_group Phospho.ELM 7.0 ViewAnalyzing
35IKBKBIKKB_HUMANS695QPSTA S NSLPE 27.34%IKKb HPRD:04462(in vitro)  ViewAnalyzing
36IKBKBIKKB_HUMANS695QPSTA S NSLPE 27.34%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
37IKBKBIKKB_HUMANS695QPSTA S NSLPE 27.34%IKK_group Phospho.ELM 7.0 ViewAnalyzing
38IKBKBIKKB_HUMANS697STASN S LPEPA 42.69%IKKb HPRD:04462(in vitro)  ViewAnalyzing
39IKBKBIKKB_HUMANS697STASN S LPEPA 42.69%IKK_group Phospho.ELM 7.0 ViewAnalyzing
40IKBKBIKKB_HUMANS697STASN S LPEPA 42.69%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
41IKBKBIKKB_HUMANS705EPAKK S EELVA 35.28%IKK_group Phospho.ELM 7.0 ViewAnalyzing
42IKBKBIKKB_HUMANS705EPAKK S EELVA 35.28%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
43IKBKBIKKB_HUMANS705EPAKK S EELVA 35.28%IKKb HPRD:04462(in vitro)  ViewAnalyzing
44IKBKBIKKB_HUMANS733REQDQ S FTALD 32.62%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
45IKBKBIKKB_HUMANS733REQDQ S FTALD 32.62%IKKb HPRD:04462(in vitro)  ViewAnalyzing
46IKBKBIKKB_HUMANS733REQDQ S FTALD 32.62%IKK_group Phospho.ELM 7.0 ViewAnalyzing
47IKBKBIKKB_HUMANS740TALDW S WLQTE 19.99%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
48IKBKBIKKB_HUMANS740TALDW S WLQTE 19.99%IKKb HPRD:04462(in vitro)  ViewAnalyzing
49IKBKBIKKB_HUMANS740TALDW S WLQTE 19.99%IKK_group Phospho.ELM 7.0 ViewAnalyzing
50IKBKBIKKB_HUMANS750EEEEH S CLEQA 24.55%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
51IKBKBIKKB_HUMANS750EEEEH S CLEQA 24.55%IKK_group Phospho.ELM 7.0 ViewAnalyzing
52IKBKBIKKB_HUMANS750EEEEH S CLEQA 24.55%IKKb HPRD:04462(in vitro)  ViewAnalyzing
53IKBKBIKKB_HUMANS756CLEQA S  40.21%IKKb HPRD:04462(in vitro)  ViewAnalyzing