Regulatory Network in Protein Phosphorylation
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Substrate: NFKB2

Description: Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2)(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10)(Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

Synonyms: LYT10

Ensembl ID: ENSG00000077150

UniprotKB/SwissProt: NFKB2_HUMAN (Q00653)

Function: Appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
PDB:1A3Q
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NFKB2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NFKB2NFKB2_HUMANS713PPTSD S DSDSE 38.49% Swiss-Prot 55.0 View   
2NFKB2NFKB2_HUMANS715TSDSD S DSEGP 47.16% Swiss-Prot 55.0 View   
3NFKB2NFKB2_HUMANS717DSDSD S EGPEK 48.70% Swiss-Prot 55.0 View   
4NFKB2NFKB2_HUMANS866EVKED S AYGSQ 25.20%NIK(MAP3K14) Phospho.ELM 7.0 ViewAnalyzing
5NFKB2NFKB2_HUMANS866EVKED S AYGSQ 25.20%NIK HPRD:01239(in vitro)  ViewAnalyzing
6NFKB2NFKB2_HUMANS866EVKED S AYGSQ 25.20%NIK(MAP3K14) Swiss-Prot 55.0  ViewAnalyzing
7NFKB2NFKB2_HUMANS870DSAYG S QSVEQ 13.45%NIK HPRD:01239(in vitro)  ViewAnalyzing
8NFKB2NFKB2_HUMANS870DSAYG S QSVEQ 13.45%NIK(MAP3K14) Phospho.ELM 7.0 ViewAnalyzing
9NFKB2NFKB2_HUMANS870DSAYG S QSVEQ 13.45%NIK(MAP3K14) Swiss-Prot 55.0  ViewAnalyzing
10NFKB2NFKB2_HUMANS872AYGSQ S VEQEA 29.35%IKKa(IKK alpha) Phospho.ELM 7.0 ViewAnalyzing