|Description: Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2)(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10)(Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].|
Ensembl ID: ENSG00000077150
UniprotKB/SwissProt: NFKB2_HUMAN (Q00653)
Function: Appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).