Regulatory Network in Protein Phosphorylation
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Substrate: TAOK3

Description: Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and oneamino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Dendritic cell-derived protein kinase) (CutaneousT-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09)(Kinase from chicken homolog A) (hKFC-A).

Synonyms: DPK, JIK, KDS, MAP3K18

Ensembl ID: ENSG00000135090

UniprotKB/SwissProt: TAOK3_HUMAN (Q9H2K8)

Function: Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TAOK3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TAOK3TAOK3_HUMANT181NSFVG T PYWMA 14.11%SLK HPRD:11620(in vitro)  ViewAnalyzing
2TAOK3TAOK3_HUMANY183FVGTP Y WMAPE 13.98%SLK HPRD:11620(in vitro)  ViewAnalyzing
3TAOK3TAOK3_HUMANS324GPLNE S QEDEE 37.48% Swiss-Prot 55.0 View   
4TAOK3TAOK3_HUMANS331EDEED S EHGTS 34.47% Swiss-Prot 55.0 View   
5TAOK3TAOK3_HUMANS346MDSLG S NHSIP 36.34% Swiss-Prot 55.0 (Similarity)View   
6TAOK3TAOK3_HUMANS349LGSNH S IPSMS 40.21% Swiss-Prot 55.0 (Similarity)View