Regulatory Network in Protein Phosphorylation
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Substrate: MARK1

Description: Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubuleaffinity-regulating kinase 1).

Synonyms: KIAA1477, MARK

Ensembl ID: ENSG00000116141

UniprotKB/SwissProt: MARK1_HUMAN (Q9P0L2)

Function: May play a role in cytoskeletal stability (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Note=Appears to localize to an intracellular network (By similarity).
PDB:2HAK
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MARK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MARK1MARK1_HUMANT215GNKLD T FCGSP 31.12% HPRD:07353(in vitro)View   
2MARK1MARK1_HUMANT215GNKLD T FCGSP 31.12%TAO1 HPRD:07353(in vitro)  ViewAnalyzing
3MARK1MARK1_HUMANT215GNKLD T FCGSP 31.12%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
4MARK1MARK1_HUMANT215GNKLD T FCGSP 31.12%LKB1 HPRD:07353(in vitro;in vivo)  ViewAnalyzing
5MARK1MARK1_HUMANT215GNKLD T FCGSP 31.12% Swiss-Prot 55.0 View   
6MARK1MARK1_HUMANS219DTFCG S PPYAA 24.71% HPRD:07353(in vitro)View   
7MARK1MARK1_HUMANS219DTFCG S PPYAA 24.71%LKB1 HPRD:07353(in vitro;in vivo)  ViewAnalyzing
8MARK1MARK1_HUMANS219DTFCG S PPYAA 24.71% Swiss-Prot 55.0 (Similarity)View   
9MARK1MARK1_HUMANS394RSRPS S DLNNS 49.12% Swiss-Prot 55.0 (Similarity)View   
10MARK1MARK1_HUMANS403NSTLQ S PAHLK 27.45% Swiss-Prot 55.0 (Similarity)View   
11MARK1MARK1_HUMANS649ARRGT S TGIIS 27.71% Swiss-Prot 55.0 View   
12MARK1MARK1_HUMANS649ARRGT S TGIIS 27.71% Phospho.ELM 7.0View   
13MARK1MARK1_HUMANS666VRRDP S EGEAS 63.62% Swiss-Prot 55.0 (Similarity)View