Regulatory Network in Protein Phosphorylation
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Substrate: ABL1

Description: Proto-oncogene tyrosine-protein kinase ABL1 (EC (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1).

Synonyms: ABL, JTK7

Ensembl ID: ENSG00000097007

UniprotKB/SwissProt: ABL1_HUMAN (P00519)

Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ABL1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ABL1ABL1_HUMANY185SDGKL Y VSSES 11.19% HPRD:01809(in vivo)View   
2ABL1ABL1_HUMANY185SDGKL Y VSSES 11.19% Phospho.ELM 7.0View   
3ABL1ABL1_HUMANY185SDGKL Y VSSES 11.19% Swiss-Prot 55.0 View   
4ABL1ABL1_HUMANY226NKPTV Y GVSPN 17.81% Phospho.ELM 7.0View   
5ABL1ABL1_HUMANY226NKPTV Y GVSPN 17.81%SRC HPRD:01809(in vivo)  ViewAnalyzing
6ABL1ABL1_HUMANY226NKPTV Y GVSPN 17.81%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
7ABL1ABL1_HUMANY226NKPTV Y GVSPN 17.81%ABL1 HPRD:01809(in vivo)  ViewAnalyzing
8ABL1ABL1_HUMANY253LGGGQ Y GEVYE 20.66% HPRD:01809(in vivo)View   
9ABL1ABL1_HUMANY253LGGGQ Y GEVYE 20.66% Swiss-Prot 55.0 View   
10ABL1ABL1_HUMANY257QYGEV Y EGVWK 11.58% HPRD:01809(in vivo)View   
11ABL1ABL1_HUMANY257QYGEV Y EGVWK 11.58% Swiss-Prot 55.0 View   
12ABL1ABL1_HUMANY264GVWKK Y SLTVA 12.75% Swiss-Prot 55.0 View   
13ABL1ABL1_HUMANY264GVWKK Y SLTVA 12.75% Phospho.ELM 7.0View   
14ABL1ABL1_HUMANY264GVWKK Y SLTVA 12.75% HPRD:01809(in vivo)View   
15ABL1ABL1_HUMANY393MTGDT Y TAHAG 13.48%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
16ABL1ABL1_HUMANY393MTGDT Y TAHAG 13.48%SRC HPRD:01809(in vitro;in vivo)  ViewAnalyzing
17ABL1ABL1_HUMANY393MTGDT Y TAHAG 13.48%Src Phospho.ELM 7.0  ViewAnalyzing
18ABL1ABL1_HUMANY393MTGDT Y TAHAG 13.48%SRC_group Swiss-Prot 55.0  ViewAnalyzing
19ABL1ABL1_HUMANY393MTGDT Y TAHAG 13.48%ABL1 Phospho.ELM 7.0  ViewAnalyzing
20ABL1ABL1_HUMANT394TGDTY T AHAGA 17.66% Phospho.ELM 7.0View   
21ABL1ABL1_HUMANT394TGDTY T AHAGA 17.66% HPRD:01809(in vivo)View   
22ABL1ABL1_HUMANT394TGDTY T AHAGA 17.66% Swiss-Prot 55.0 View   
23ABL1ABL1_HUMANS446PGIDL S QVYEL 17.53% Swiss-Prot 55.0 (Similarity)View   
24ABL1ABL1_HUMANS446PGIDL S QVYEL 17.53%ATM Phospho.ELM 7.0  ViewAnalyzing
25ABL1ABL1_HUMANS446PGIDL S QVYEL 17.53%ATM HPRD:01809(in vivo)  ViewAnalyzing
26ABL1ABL1_HUMANS446PGIDL S QVYEL 17.53% HPRD:01809(in vitro;in vivo)View   
27ABL1ABL1_HUMANY469CPEKV Y ELMRA 17.89%ABL1 HPRD:01809(in vivo)  ViewAnalyzing
28ABL1ABL1_HUMANY469CPEKV Y ELMRA 17.89%SRC HPRD:01809(in vivo)  ViewAnalyzing
29ABL1ABL1_HUMANY469CPEKV Y ELMRA 17.89% Swiss-Prot 55.0 View   
30ABL1ABL1_HUMANS569HEPAV S PLLPR 16.37% Swiss-Prot 55.0 View   
31ABL1ABL1_HUMANS569HEPAV S PLLPR 16.37% Phospho.ELM 7.0View   
32ABL1ABL1_HUMANS569HEPAV S PLLPR 16.37%CDC2 HPRD:01809(in vitro;in vivo)  ViewAnalyzing
33ABL1ABL1_HUMANS683GSGFR S PHLWK 17.89% Swiss-Prot 55.0 View   
34ABL1ABL1_HUMANT735EWRSV T LPRDL 32.09% HPRD:01809(in vivo)View   
35ABL1ABL1_HUMANS805DIMES S PGSSP 21.70% Swiss-Prot 55.0 View   
36ABL1ABL1_HUMANS809SSPGS S PPNLT 50.74% Swiss-Prot 55.0 View   
37ABL1ABL1_HUMANS949DAAKP S QPGEG 48.58% Swiss-Prot 55.0 View   
38ABL1ABL1_HUMANS949DAAKP S QPGEG 48.58% Phospho.ELM 7.0View