|Description: Proto-oncogene tyrosine-protein kinase ABL1 (EC 18.104.22.168) (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1).|
Synonyms: ABL, JTK7
Ensembl ID: ENSG00000097007
UniprotKB/SwissProt: ABL1_HUMAN (P00519)
Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.